{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cosorich I"],"funding":["Fondazione Italiana Sclerosi Multipla"],"pagination":["e1700492"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5507635"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(7)"],"pubmed_abstract":["T helper 17 (T<sub>H</sub>17) cells are key players in multiple sclerosis (MS), and studies in animal models demonstrated that effector T<sub>H</sub>17 cells that trigger brain autoimmunity originate in the intestine. We validate in humans the crucial role of the intestinal environment in promoting T<sub>H</sub>17 cell expansion in MS patients. We found that increased frequency of T<sub>H</sub>17 cells correlates with high disease activity and with specific alterations of the gut mucosa-associated microbiota in MS patients. By using 16<i>S</i> ribosomal RNA sequencing, we analyzed the microbiota isolated from small intestinal tissues and found that MS patients with high disease activity and increased intestinal T<sub>H</sub>17 cell frequency showed a higher Firmicutes/Bacteroidetes ratio, increased relative abundance of <i>Streptococcus</i>, and decreased <i>Prevotella</i> strains compared to healthy controls and MS patients with no disease activity. We demonstrated that the intestinal T<sub>H</sub>17 cell frequency is inversely related to the relative abundance of <i>Prevotella</i> strains in the human small intestine. Our data demonstrate that brain autoimmunity is associated with specific microbiota modifications and excessive T<sub>H</sub>17 cell expansion in the human intestine."],"journal":["Science advances"],"pubmed_title":["High frequency of intestinal T<sub>H</sub>17 cells correlates with microbiota alterations and disease activity in multiple sclerosis."],"pmcid":["PMC5507635"],"funding_grant_id":["award330486"],"pubmed_authors":["Martinelli V","Testoni PA","Dolpady J","Sorini C","Falcone M","Messina MJ","Radice E","Comi G","Canducci F","Ferrarese R","Cosorich I","Mariani A","Dalla-Costa G"],"additional_accession":[]},"is_claimable":false,"name":"High frequency of intestinal T<sub>H</sub>17 cells correlates with microbiota alterations and disease activity in multiple sclerosis.","description":"T helper 17 (T<sub>H</sub>17) cells are key players in multiple sclerosis (MS), and studies in animal models demonstrated that effector T<sub>H</sub>17 cells that trigger brain autoimmunity originate in the intestine. We validate in humans the crucial role of the intestinal environment in promoting T<sub>H</sub>17 cell expansion in MS patients. We found that increased frequency of T<sub>H</sub>17 cells correlates with high disease activity and with specific alterations of the gut mucosa-associated microbiota in MS patients. By using 16<i>S</i> ribosomal RNA sequencing, we analyzed the microbiota isolated from small intestinal tissues and found that MS patients with high disease activity and increased intestinal T<sub>H</sub>17 cell frequency showed a higher Firmicutes/Bacteroidetes ratio, increased relative abundance of <i>Streptococcus</i>, and decreased <i>Prevotella</i> strains compared to healthy controls and MS patients with no disease activity. We demonstrated that the intestinal T<sub>H</sub>17 cell frequency is inversely related to the relative abundance of <i>Prevotella</i> strains in the human small intestine. Our data demonstrate that brain autoimmunity is associated with specific microbiota modifications and excessive T<sub>H</sub>17 cell expansion in the human intestine.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jul","modification":"2025-04-18T20:41:22.942Z","creation":"2019-03-26T23:25:23Z"},"accession":"S-EPMC5507635","cross_references":{"pubmed":["28706993"],"doi":["10.1126/sciadv.1700492"]}}