{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["97(1)"],"submitter":["Schilling KA"],"pubmed_abstract":["Diarrheal disease is a leading cause of death among young children worldwide. As rates of acute diarrhea (AD; 1-6 days duration) have decreased, persistent diarrhea (PD; > 14 days duration) accounts for a greater proportion of the diarrheal disease burden. We describe factors associated with the duration of moderate-to-severe diarrhea in Kenyan children < 5 years old enrolled in the Global Enteric Multicenter Study. We found 587 (58%) children experienced AD, 360 (35%) had prolonged acute diarrhea (ProAD; 7-13 days duration), and 73 (7%) had PD. We constructed a Cox proportional hazards model to identify factors associated with diarrheal duration. Risk factors independently associated with longer diarrheal duration included infection with <i>Cryptosporidium</i> (hazard ratio [HR]: 0.868, <"],"journal":["The American journal of tropical medicine and hygiene"],"pagination":["248-258"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5508904"],"repository":["biostudies-literature"],"pubmed_title":["Factors Associated with the Duration of Moderate-to-Severe Diarrhea among Children in Rural Western Kenya Enrolled in the Global Enteric Multicenter Study, 2008-2012."],"pmcid":["PMC5508904"],"pubmed_authors":["Bopp C","Kotloff KL","Omore R","Farag TH","Rothenberg R","Levine MM","Oundo J","Panchalingam S","Ochieng JB","O'Reilly CE","Derado G","Parsons MB","Stauber CE","Ayers T","Nasrin D","Nataro JP","Breiman RF","Laserson K","Schilling KA","Mintz ED"],"additional_accession":[]},"is_claimable":false,"name":"Factors Associated with the Duration of Moderate-to-Severe Diarrhea among Children in Rural Western Kenya Enrolled in the Global Enteric Multicenter Study, 2008-2012.","description":"Diarrheal disease is a leading cause of death among young children worldwide. As rates of acute diarrhea (AD; 1-6 days duration) have decreased, persistent diarrhea (PD; > 14 days duration) accounts for a greater proportion of the diarrheal disease burden. We describe factors associated with the duration of moderate-to-severe diarrhea in Kenyan children < 5 years old enrolled in the Global Enteric Multicenter Study. We found 587 (58%) children experienced AD, 360 (35%) had prolonged acute diarrhea (ProAD; 7-13 days duration), and 73 (7%) had PD. We constructed a Cox proportional hazards model to identify factors associated with diarrheal duration. Risk factors independently associated with longer diarrheal duration included infection with <i>Cryptosporidium</i> (hazard ratio [HR]: 0.868, <","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jul","modification":"2025-04-18T20:42:23.248Z","creation":"2019-03-26T23:45:36Z"},"accession":"S-EPMC5508904","cross_references":{"pubmed":["28719331"],"doi":["10.4269/ajtmh.16-0898"]}}