biostudies-literatureUnknown97(1)Schilling KADiarrheal disease is a leading cause of death among young children worldwide. As rates of acute diarrhea (AD; 1-6 days duration) have decreased, persistent diarrhea (PD; > 14 days duration) accounts for a greater proportion of the diarrheal disease burden. We describe factors associated with the duration of moderate-to-severe diarrhea in Kenyan children < 5 years old enrolled in the Global Enteric Multicenter Study. We found 587 (58%) children experienced AD, 360 (35%) had prolonged acute diarrhea (ProAD; 7-13 days duration), and 73 (7%) had PD. We constructed a Cox proportional hazards model to identify factors associated with diarrheal duration. Risk factors independently associated with longer diarrheal duration included infection with <i>Cryptosporidium</i> (hazard ratio [HR]: 0.868, <The American journal of tropical medicine and hygiene248-258https://www.ebi.ac.uk/biostudies/studies/S-EPMC5508904biostudies-literatureFactors Associated with the Duration of Moderate-to-Severe Diarrhea among Children in Rural Western Kenya Enrolled in the Global Enteric Multicenter Study, 2008-2012.PMC5508904Bopp CKotloff KLOmore RFarag THRothenberg RLevine MMOundo JPanchalingam SOchieng JBO'Reilly CEDerado GParsons MBStauber CEAyers TNasrin DNataro JPBreiman RFLaserson KSchilling KAMintz EDfalseFactors Associated with the Duration of Moderate-to-Severe Diarrhea among Children in Rural Western Kenya Enrolled in the Global Enteric Multicenter Study, 2008-2012.Diarrheal disease is a leading cause of death among young children worldwide. As rates of acute diarrhea (AD; 1-6 days duration) have decreased, persistent diarrhea (PD; > 14 days duration) accounts for a greater proportion of the diarrheal disease burden. We describe factors associated with the duration of moderate-to-severe diarrhea in Kenyan children < 5 years old enrolled in the Global Enteric Multicenter Study. We found 587 (58%) children experienced AD, 360 (35%) had prolonged acute diarrhea (ProAD; 7-13 days duration), and 73 (7%) had PD. We constructed a Cox proportional hazards model to identify factors associated with diarrheal duration. Risk factors independently associated with longer diarrheal duration included infection with <i>Cryptosporidium</i> (hazard ratio [HR]: 0.868, <2017-01-01T00:00:00Z2017 Jul2025-04-18T20:42:23.248Z2019-03-26T23:45:36ZS-EPMC55089042871933110.4269/ajtmh.16-0898