{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["61(4)"],"submitter":["Godoy LD"],"funding":["National Institute of General Medical Sciences","National Institute of Food and Agriculture","NIGMS NIH HHS"],"pubmed_abstract":["<h4>Scope</h4>Nutrigenomics is a rapidly expanding field that elucidates the link between diet-genome interactions. Recent evidence demonstrates that regulation of the epigenome, and in particular inhibition of histone deacetylases (HDACs), impact pathogenetic mechanisms involved in chronic disease. Few studies, to date, have screened libraries of bioactive compounds that act as epigenetic modifiers. This study screened a library of 131 natural compounds to determine bioactive compounds that inhibit Zn-dependent HDAC activity.<h4>Methods and results</h4>Using class-specific HDAC substrates, we screened 131 natural compounds for HDAC activity in bovine cardiac tissue. From this screen, we identified 18 bioactive compound HDAC inhibitors. Using our class-specific HDAC substrates, we next scr"],"journal":["Molecular nutrition & food research"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5508980"],"repository":["biostudies-literature"],"pubmed_title":["Targeting the epigenome: Screening bioactive compounds that regulate histone deacetylase activity."],"pmcid":["PMC5508980"],"funding_grant_id":["Hatch‐NEV00727","P20 GM103554"],"pubmed_authors":["Romanick SS","Lucas JE","Bender AJ","Ferguson BS","Godoy LD"],"additional_accession":[]},"is_claimable":false,"name":"Targeting the epigenome: Screening bioactive compounds that regulate histone deacetylase activity.","description":"<h4>Scope</h4>Nutrigenomics is a rapidly expanding field that elucidates the link between diet-genome interactions. Recent evidence demonstrates that regulation of the epigenome, and in particular inhibition of histone deacetylases (HDACs), impact pathogenetic mechanisms involved in chronic disease. Few studies, to date, have screened libraries of bioactive compounds that act as epigenetic modifiers. This study screened a library of 131 natural compounds to determine bioactive compounds that inhibit Zn-dependent HDAC activity.<h4>Methods and results</h4>Using class-specific HDAC substrates, we screened 131 natural compounds for HDAC activity in bovine cardiac tissue. From this screen, we identified 18 bioactive compound HDAC inhibitors. Using our class-specific HDAC substrates, we next scr","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Apr","modification":"2025-04-19T22:42:16.776Z","creation":"2019-03-26T23:22:22Z"},"accession":"S-EPMC5508980","cross_references":{"pubmed":["27981795"],"doi":["10.1002/mnfr.201600744"]}}