{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(6)"],"submitter":["Dinh QN"],"pubmed_abstract":["Aging is commonly associated with chronic low-grade inflammation and hypertension but it is unknown whether a cause-effect relationship exists between them. We compared the sensitivity of young adult (8-12 w) and aged (23-31 mo) male C57Bl6J mice to develop hypertension in response to a slow-pressor dose of angiotensin II (Ang II; 0.28 mg/kg/d; 28 d). In young mice, the pressor response to Ang II was gradual and increased to 142±8 mmHg over 28 d. However, in aged mice, Ang II promptly increased SBP and reached 155±12 mmHg by 28 d. Aging increased renal but not brain expression of Ang II receptors (<i>At1ar</i> and <i>At2r</i>) and elevated AT1R:AT2R expression ratio in mesenteric artery. Maximal contractile responses of mesenteric arteries to Ang II were enhanced in aged mice and were not "],"journal":["Aging"],"pagination":["1595-1606"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5509458"],"repository":["biostudies-literature"],"pubmed_title":["Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress."],"pmcid":["PMC5509458"],"pubmed_authors":["Chrissobolis S","Kemp-Harper BK","Vinh A","Diep H","Robertson AAB","Mansell A","Drummond GR","De Silva TM","Cooper MA","Dinh QN","Sobey CG","Kim HA"],"additional_accession":[]},"is_claimable":false,"name":"Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress.","description":"Aging is commonly associated with chronic low-grade inflammation and hypertension but it is unknown whether a cause-effect relationship exists between them. We compared the sensitivity of young adult (8-12 w) and aged (23-31 mo) male C57Bl6J mice to develop hypertension in response to a slow-pressor dose of angiotensin II (Ang II; 0.28 mg/kg/d; 28 d). In young mice, the pressor response to Ang II was gradual and increased to 142±8 mmHg over 28 d. However, in aged mice, Ang II promptly increased SBP and reached 155±12 mmHg by 28 d. Aging increased renal but not brain expression of Ang II receptors (<i>At1ar</i> and <i>At2r</i>) and elevated AT1R:AT2R expression ratio in mesenteric artery. Maximal contractile responses of mesenteric arteries to Ang II were enhanced in aged mice and were not ","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jun","modification":"2025-04-18T20:42:23.952Z","creation":"2019-03-27T02:50:22Z"},"accession":"S-EPMC5509458","cross_references":{"pubmed":["28659507"],"doi":["10.18632/aging.101255"]}}