biostudies-literatureUnknown9(6)Dinh QNAging is commonly associated with chronic low-grade inflammation and hypertension but it is unknown whether a cause-effect relationship exists between them. We compared the sensitivity of young adult (8-12 w) and aged (23-31 mo) male C57Bl6J mice to develop hypertension in response to a slow-pressor dose of angiotensin II (Ang II; 0.28 mg/kg/d; 28 d). In young mice, the pressor response to Ang II was gradual and increased to 142±8 mmHg over 28 d. However, in aged mice, Ang II promptly increased SBP and reached 155±12 mmHg by 28 d. Aging increased renal but not brain expression of Ang II receptors (<i>At1ar</i> and <i>At2r</i>) and elevated AT1R:AT2R expression ratio in mesenteric artery. Maximal contractile responses of mesenteric arteries to Ang II were enhanced in aged mice and were not Aging1595-1606https://www.ebi.ac.uk/biostudies/studies/S-EPMC5509458biostudies-literaturePressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress.PMC5509458Chrissobolis SKemp-Harper BKVinh ADiep HRobertson AABMansell ADrummond GRDe Silva TMCooper MADinh QNSobey CGKim HAfalsePressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress.Aging is commonly associated with chronic low-grade inflammation and hypertension but it is unknown whether a cause-effect relationship exists between them. We compared the sensitivity of young adult (8-12 w) and aged (23-31 mo) male C57Bl6J mice to develop hypertension in response to a slow-pressor dose of angiotensin II (Ang II; 0.28 mg/kg/d; 28 d). In young mice, the pressor response to Ang II was gradual and increased to 142±8 mmHg over 28 d. However, in aged mice, Ang II promptly increased SBP and reached 155±12 mmHg by 28 d. Aging increased renal but not brain expression of Ang II receptors (<i>At1ar</i> and <i>At2r</i>) and elevated AT1R:AT2R expression ratio in mesenteric artery. Maximal contractile responses of mesenteric arteries to Ang II were enhanced in aged mice and were not 2017-01-01T00:00:00Z2017 Jun2025-04-18T20:42:23.952Z2019-03-27T02:50:22ZS-EPMC55094582865950710.18632/aging.101255