biostudies-literatureTian RNational Cancer InstituteNational Institutes of Health through Cancer CenterNCI NIH HHSCancer Prevention Research Institute of Texas77-83https://www.ebi.ac.uk/biostudies/studies/S-EPMC5509529biostudies-literatureUnknown132Mounting evidence supports a mechanistic link between inflammation and cancer, especially colon cancer. ALOX15 (15-lipoxygenase-1) plays an important role in the formation of key lipid mediators (e.g., lipoxins and resolvins) to terminate inflammation. ALOX15 expression is downregulated in colorectal cancer (CRC). Intestinally-targeted transgenic expression of ALOX15 in mice inhibited dextran sodium sulfate-induced colitis from promoting azoxymethane- induced colorectal tumorigenesis, demonstrating that ALOX15 can suppress inflammation-driven promotion of carcinogen-induced colorectal tumorigenesis and therefore ALOX15 downregulation during tumorigenesis is likely to enhance the link between colitis and colorectal tumorigenesis. ALOX15 suppressed the TNF-α, IL-1β/NF-κB, and IL-6/STAT3 signProstaglandins & other lipid mediatorsALOX15 as a suppressor of inflammation and cancer: Lost in the link.PMC5509529R01 CA195686CA016672R01-CA 195686P30 CA016672RP140224R01 CA206539R01-CA 206539RP150195Jaoude JShureiqi IZuo XTian RColby JMao FfalseALOX15 as a suppressor of inflammation and cancer: Lost in the link.Mounting evidence supports a mechanistic link between inflammation and cancer, especially colon cancer. ALOX15 (15-lipoxygenase-1) plays an important role in the formation of key lipid mediators (e.g., lipoxins and resolvins) to terminate inflammation. ALOX15 expression is downregulated in colorectal cancer (CRC). Intestinally-targeted transgenic expression of ALOX15 in mice inhibited dextran sodium sulfate-induced colitis from promoting azoxymethane- induced colorectal tumorigenesis, demonstrating that ALOX15 can suppress inflammation-driven promotion of carcinogen-induced colorectal tumorigenesis and therefore ALOX15 downregulation during tumorigenesis is likely to enhance the link between colitis and colorectal tumorigenesis. ALOX15 suppressed the TNF-α, IL-1β/NF-κB, and IL-6/STAT3 sign2017-01-01T00:00:00Z2017 Sep2025-04-19T22:40:50.646Z2019-03-26T23:53:00ZS-EPMC55095292808973210.1016/j.prostaglandins.2017.01.002