{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(2)"],"submitter":["Grußer L"],"pubmed_abstract":["Despite years of research, treatment of traumatic brain injury (TBI) remains challenging. Considerable data exists that some volatile anesthetics might be neuroprotective. However, several studies have also revealed a rather neurotoxic profile of anesthetics. In this study, we investigated the effects of argon 50%, desflurane 6% and their combination in an <i>in vitro</i> TBI model with incubation times similar to narcotic time slots in a daily clinical routine. Organotypic hippocampal brain slices of 5- to 7-day-old mice were cultivated for 14 days before TBI was performed. Slices were eventually incubated for 2 hours in an atmosphere containing no anesthetic gas, argon 50% or desflurane 6% or both. Trauma intensity was evaluated <i>via</i> fluorescent imagery. Our results show that neith"],"journal":["Medical gas research"],"pagination":["93-100"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5510299"],"repository":["biostudies-literature"],"pubmed_title":["Argon attenuates the emergence of secondary injury after traumatic brain injury within a 2-hour incubation period compared to desflurane: an <i>in vitro</i> study."],"pmcid":["PMC5510299"],"pubmed_authors":["Hollig A","Grußer L","Blaumeiser-Debarry R","Kremer B","Rossaint R","Coburn M","Krings M"],"additional_accession":[]},"is_claimable":false,"name":"Argon attenuates the emergence of secondary injury after traumatic brain injury within a 2-hour incubation period compared to desflurane: an <i>in vitro</i> study.","description":"Despite years of research, treatment of traumatic brain injury (TBI) remains challenging. Considerable data exists that some volatile anesthetics might be neuroprotective. However, several studies have also revealed a rather neurotoxic profile of anesthetics. In this study, we investigated the effects of argon 50%, desflurane 6% and their combination in an <i>in vitro</i> TBI model with incubation times similar to narcotic time slots in a daily clinical routine. Organotypic hippocampal brain slices of 5- to 7-day-old mice were cultivated for 14 days before TBI was performed. Slices were eventually incubated for 2 hours in an atmosphere containing no anesthetic gas, argon 50% or desflurane 6% or both. Trauma intensity was evaluated <i>via</i> fluorescent imagery. Our results show that neith","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Apr-Jun","modification":"2025-04-18T20:41:17.914Z","creation":"2019-03-27T02:50:26Z"},"accession":"S-EPMC5510299","cross_references":{"pubmed":["28744361"],"doi":["10.4103/2045-9912.208512"]}}