{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ribeiro EA"],"funding":["NIDA NIH HHS","NIMH NIH HHS","NIH HHS"],"pagination":["5412"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5511210"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(1)"],"pubmed_abstract":["Metabolic and functional alterations of neurons in the dorsolateral prefrontal cortex (dlPFC) are thought to contribute to impulsivity, which is a hallmark of addictive behaviors that underlie compulsive drug seeking and taking in humans. To determine if there is a transcriptional signature in dlPFC neurons of humans with cocaine use disorder, we performed total RNA-sequencing on neuronal nuclei isolated from post-mortem dlPFC of cocaine addicts and healthy controls. Our results point toward a transcriptional mechanism whereby cocaine alters specific gene networks in dlPFC neurons. In particular, we identified an AP-1 regulated transcriptional network in dlPFC neurons associated with cocaine use disorder that contains several differentially expressed hub genes. Several of these hub genes a"],"journal":["Scientific reports"],"pubmed_title":["Gene Network Dysregulation in Dorsolateral Prefrontal Cortex Neurons of Humans with Cocaine Use Disorder."],"pmcid":["PMC5511210"],"funding_grant_id":["R37 DA007359","F30 MH106293","P01 DA008227","S10 OD018522"],"pubmed_authors":["Ribeiro EA","Scarpa JR","Garamszegi SP","Kasarskis A","Mash DC","Nestler EJ"],"additional_accession":[]},"is_claimable":false,"name":"Gene Network Dysregulation in Dorsolateral Prefrontal Cortex Neurons of Humans with Cocaine Use Disorder.","description":"Metabolic and functional alterations of neurons in the dorsolateral prefrontal cortex (dlPFC) are thought to contribute to impulsivity, which is a hallmark of addictive behaviors that underlie compulsive drug seeking and taking in humans. To determine if there is a transcriptional signature in dlPFC neurons of humans with cocaine use disorder, we performed total RNA-sequencing on neuronal nuclei isolated from post-mortem dlPFC of cocaine addicts and healthy controls. Our results point toward a transcriptional mechanism whereby cocaine alters specific gene networks in dlPFC neurons. In particular, we identified an AP-1 regulated transcriptional network in dlPFC neurons associated with cocaine use disorder that contains several differentially expressed hub genes. Several of these hub genes a","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jul","modification":"2025-04-18T13:37:50.128Z","creation":"2025-04-06T23:25:07.382Z"},"accession":"S-EPMC5511210","cross_references":{"pubmed":["28710498"],"doi":["10.1038/s41598-017-05720-3"]}}