biostudies-literatureUnknown13(7)Xu XChimeric antigen receptor T cells are T cells genetically engineered with CAR constructs which mainly contain scFV and TCR zeta chain. With promising development in blood cancers, CAR T trials are also applied in solid cancers. However, the treatment effect in solid cancers is lower than expected. This review summarizes difference of CAR T applications in solid and blood cancers. Future challenges of CAR T cell treatment in solid cancer are also discussed using ovarian cancer as an example.Human vaccines & immunotherapeutics1548-1555https://www.ebi.ac.uk/biostudies/studies/S-EPMC5512759biostudies-literatureThe basics of CAR T design and challenges in immunotherapy of solid tumors - Ovarian cancer as a model.PMC5512759Qiu JXu XSun YfalseThe basics of CAR T design and challenges in immunotherapy of solid tumors - Ovarian cancer as a model.Chimeric antigen receptor T cells are T cells genetically engineered with CAR constructs which mainly contain scFV and TCR zeta chain. With promising development in blood cancers, CAR T trials are also applied in solid cancers. However, the treatment effect in solid cancers is lower than expected. This review summarizes difference of CAR T applications in solid and blood cancers. Future challenges of CAR T cell treatment in solid cancer are also discussed using ovarian cancer as an example.2017-01-01T00:00:00Z2017 Jul2025-04-19T18:42:55.275Z2019-03-26T23:06:43ZS-EPMC55127592827296710.1080/21645515.2017.1291473