biostudies-literature00540Puhan MANHLBI NIH HHS784-90https://www.ebi.ac.uk/biostudies/studies/S-EPMC5516638biostudies-literatureUnknown37(4)Our aim was to determine the minimal important difference (MID) for 6-min walk distance (6MWD) and maximal cycle exercise capacity (MCEC) in patients with severe chronic obstructive pulmonary disease (COPD). 1,218 patients enrolled in the National Emphysema Treatment Trial completed exercise tests before and after 4-6 weeks of pre-trial rehabilitation, and 6 months after randomisation to surgery or medical care. The St George's Respiratory Questionnaire (domain and total scores) and University of California San Diego Shortness of Breath Questionnaire (total score) served as anchors for anchor-based MID estimates. In order to calculate distribution-based estimates, we used the standard error of measurement, Cohen's effect size and the empirical rule effect size. Anchor-based estimates for the 6MWD were 18.9 m (95% CI 18.1-20.1 m), 24.2 m (95% CI 23.4-25.4 m), 24.6 m (95% CI 23.4-25.7 m) and 26.4 m (95% CI 25.4-27.4 m), which were similar to distribution-based MID estimates of 25.7, 26.8 and 30.6 m. For MCEC, anchor-based estimates for the MID were 2.2 W (95% CI 2.0-2.4 W), 3.2 W (95% CI 3.0-3.4 W), 3.2 W (95% CI 3.0-3.4 W) and 3.3 W (95% CI 3.0-3.5 W), while distribution-based estimates were 5.3 and 5.5 W. We suggest a MID of 26 ± 2 m for 6MWD and 4 ± 1 W for MCEC for patients with severe COPD.The European respiratory journalThe minimal important difference of exercise tests in severe COPD.PMC5516638N01HR76104N01HR76115N01HR76103N01HR76114N01HR76106N01HR76116N01HR76105N01HR76111N01HR76110N01HR76113N01HR76102N01HR76112N01HR76101N01 HR076115N01HR76108N01HR76119N01HR76107N01HR76118N01HR76109Young CHooper SSexton JBoitano LMoskowitz IMullan BDurr TAyres GCordova FRodarte JBenedict BMcAdams HVilotijevic DDweik RLawlor BGerber RRoessler LWaldhausen JAHowe JRussell RGilmartin MKazerooni ERussell WWhite KBoiselle PNewell JLipson DQi SReardon MStanford WElliot BRoss PJulien PGillespie DMiller DRamirez CWhite CMiller CMcKenna REdell EShroyer ALEdmonds VReilly JO'Shea MWoodcock BMarglin SSimcox RDiMango AHarrell JMiller WJoyner MZisman DSnyder MKnieper VHicks DMaurer JRamsey SHaddad JGinsburg MMcSweeny AJPalevsky HGrichnik KMantinaos MCarter JPlankeel JSaunders DGilbert TVance GMcDowell PHoover EBria WWagner JMinkoff-Rau JLamb JWiener-Kronish JWilley JKotler-Klein LMartinez FSullivan SJohnson JAlavi AJhingran SChamberlain WHyatt RWeir CFlaherty KSullivan EReeves-Viets JMidthun DStoller JPropst JChatziioannou SHartman TWise RADeCamp MStolar CLimberg TTino GBerkmen YTravaline JMendez JWrona GRossoff LBelt PWrona CLarsen CTonascia JDuffy SMeli YCulver BFox PGuo JMoy MRittinger DKrasna MThomashow BMinai OLevine CNaunheim KOrens JDeMercado GWalter JIbrahim AYounes MEdgar MWinner KHowlader NDubose KHandelsman HMieras KKeller CLevine REtzioni RBaldwin JCagle PPeterson SDeVilliers PFrese SMeinert JNorris ABradt KChristensen PSchroeder TNowakowski DSnedeker SMcLennan GOpelman SMartay KSugarbaker DKaiser LGillespy TKaplan RTapson VAlcorn TWood BTsang DJellen PHubmayr RFrankville DWood DBartling SSoltoff CMilburn-Barnes MOjo TWise RHansel NNSieren JBaker EGreene DSharafkhaneh ACook-Granroth JTeague RShearer SWilliams ODGeaga CSisson TMcCreight PLockhart DSteele MDiaz PMets BMosenifar ZHibbit ABattaglia NCanterbury JRies ASax SHammel BCarino TOxorn DAukberg SNational Emphysema Treatment Trial (NETT) Research GroupWard PMottram CKraenzler EBenditt JBozzarello BAKurokawa NSheingold SRuppel GHarle JLacomis JYusen RCarney KKhan ARittinger MSheaffer HSmith JSmith PCrouch RZamora MSmith MYegyan VChapman JKotloff RPiantadosi SSiegelman SGerhardt MStone-Wynne JWilliams KWeinmann GWhalen-Price JDeshler JStavrolakes KHarpole DTaylor KFerguson MFoster GLMohsenifar ZCutler JBees TKatz MHartigan PMoskowitz AJStafford-Smith MChin JGarrett JBlackford AO'Donovan PLynch DFurukawa SLann RDo SPapatheofanis FJPoole LOsterloh JGeorge ELubell SMagliocca MOwens KMeldrum CCriner GSassi-Dambron DGeyman LClancy CMake BScharf SGolden SSilfies LDodge JDibbern PQuaife RShirey SZaremba LFishman APYip CPearson GBarnard PSykes AMEllisor MMcKeon KKalra SBernard GKirsch KDonithan MKuzma AMHarms GJenson NKazanjian PBrogan FGodwin DGill PChwalik CColvin RSimonelli PHoffman RLivingston HMcVearry KLewis MSteiger MAbel MOfficer TEdelman JMarlow SKapelanski DBerkoski PFuhlbrigge AFendrick AMJahn AKaplan RMFahs MCFuhrman CRysso PSikora CLautensack KNizami IJensen ECollison BChandra DRising PAtwell DMahler DRaymond CConejo-Gonzales KPathak DHoffman EDempsey MLHoffman JHearn CWitt CJackson REspada RHart JQuint LAronchick JAlvarez FBowdle AApostolakis JCollins KMartin UHudson CD'Alonzo GBorosh SWilson LJacobson FRicketts JWilson OSchartel SEmery CWeeks MO'Brien GButanda RGefter WKeenan RMeyers JWurster AGay SChan LKachulis BHanson KMcCarthy KHanson LLuketich JFanning CChong ABarnette RPiker CFrantz RChiang YPSciurba FIannettoni MFormanek VKleinhenz MEArcasoy SClark SDonahoe MLee STorres NWheeler CHood ESchilz RKiley JChatila WMacIntyre NEdwards BShade DSchwartz JSKarsell PHunsaker APomerantz MSwanson SDaniele RSwensen SFernandez EDavis RDHansen-Flaschen JSilver KAustin JSlivka WAllen MBosco LMehta AKleiman NBiring MKeresztury MNorten JSimon BWu MRinaldo-Gallo SSternberg AReinhardt JFollmann DSimon TToshima MCraemer STrue MCarlos MBerry KKupferberg DHale KLorenzon MKreizenbeck KBrister NBody SO'Connell RMeziane MAnable KBartels MDeMets DKrichman AFessler HBendel SColeman REFriedman PVan Natta MDelsing ADrake JKing MKing KStrollo DAughenbaugh GGurney JUtz JWahl PAndrist DAl-Amin AShiau MDeschamps CBerkowitz SMPfeffer JKwak CCampbell KNguyen CBrown MKopp TCherniack RPuhan MAFuller J54falseThe minimal important difference of exercise tests in severe COPD.Our aim was to determine the minimal important difference (MID) for 6-min walk distance (6MWD) and maximal cycle exercise capacity (MCEC) in patients with severe chronic obstructive pulmonary disease (COPD). 1,218 patients enrolled in the National Emphysema Treatment Trial completed exercise tests before and after 4-6 weeks of pre-trial rehabilitation, and 6 months after randomisation to surgery or medical care. The St George's Respiratory Questionnaire (domain and total scores) and University of California San Diego Shortness of Breath Questionnaire (total score) served as anchors for anchor-based MID estimates. In order to calculate distribution-based estimates, we used the standard error of measurement, Cohen's effect size and the empirical rule effect size. Anchor-based estimates for the 6MWD were 18.9 m (95% CI 18.1-20.1 m), 24.2 m (95% CI 23.4-25.4 m), 24.6 m (95% CI 23.4-25.7 m) and 26.4 m (95% CI 25.4-27.4 m), which were similar to distribution-based MID estimates of 25.7, 26.8 and 30.6 m. For MCEC, anchor-based estimates for the MID were 2.2 W (95% CI 2.0-2.4 W), 3.2 W (95% CI 3.0-3.4 W), 3.2 W (95% CI 3.0-3.4 W) and 3.3 W (95% CI 3.0-3.5 W), while distribution-based estimates were 5.3 and 5.5 W. We suggest a MID of 26 ± 2 m for 6MWD and 4 ± 1 W for MCEC for patients with severe COPD.2011-01-01T00:00:00Z2011 Apr2024-11-06T01:42:53.437Z2019-03-27T02:50:54ZS-EPMC55166382069324710.1183/09031936.00063810