biostudies-literatureNhat NTDWellcome Trust6060https://www.ebi.ac.uk/biostudies/studies/S-EPMC5519701biostudies-literatureUnknown7(1)Seroepidemiological studies aim to understand population-level exposure and immunity to infectious diseases. Their results are normally presented as binary outcomes describing the presence or absence of pathogen-specific antibody, despite the fact that many assays measure continuous quantities. A population's natural distribution of antibody titers to an endemic infectious disease may include information on multiple serological states - naiveté, recent infection, non-recent infection, childhood infection - depending on the disease in question and the acquisition and waning patterns of immunity. In this study, we investigate 20,152 general-population serum samples from southern Vietnam collected between 2009 and 2013 from which we report antibody titers to the influenza virus HA1 protein usScientific reportsStructure of general-population antibody titer distributions to influenza A virus.PMC5519701089276098511/Z/12/Z097465/B/11/ZHa VTHQuan TMThwaites GEVy NHTThanh NTLHung NTHuy HLAde Bruin ETodd SThao TTNLien NTNBoni MFHong TTKLam HMAnh PHNhat NTDBaker SSimmons CPChau NVVKoopmans MFarrar JVinh DNvan Beek JfalseStructure of general-population antibody titer distributions to influenza A virus.Seroepidemiological studies aim to understand population-level exposure and immunity to infectious diseases. Their results are normally presented as binary outcomes describing the presence or absence of pathogen-specific antibody, despite the fact that many assays measure continuous quantities. A population's natural distribution of antibody titers to an endemic infectious disease may include information on multiple serological states - naiveté, recent infection, non-recent infection, childhood infection - depending on the disease in question and the acquisition and waning patterns of immunity. In this study, we investigate 20,152 general-population serum samples from southern Vietnam collected between 2009 and 2013 from which we report antibody titers to the influenza virus HA1 protein us2017-01-01T00:00:00Z2017 Jul2025-04-26T12:14:54.417Z2019-03-27T02:51:07ZS-EPMC55197012872970210.1038/s41598-017-06177-0