{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(5)"],"submitter":["Xu L"],"pubmed_abstract":["Spermatogenesis, the process by which haploid sperm cells are produced from a diploid precursor cell, is essential for sexual reproduction. Here, we report that RING-finger protein 138 (Rnf138) is highly expressed in testes, especially in spermatogonia and spermatocytes. The role of Rnf138 in spermatogenesis was examined using a Rnf138-knockout mouse model. Rnf138 deficiency resulted in increased apoptosis in spermatogenic cells, loss of proliferative spermatogonia, delayed development of spermatozoa and impaired fertility. The proportion of PLZF+Ki67+ cells within the PLZF+ population decreased in the knockout mice. The phenotype was further assessed by RNA-sequencing (RNA-seq), which determined that the expression levels of many genes involved in spermatogenesis were altered in the testi"],"journal":["Cell death & disease"],"pagination":["e2795"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5520686"],"repository":["biostudies-literature"],"pubmed_title":["Rnf138 deficiency promotes apoptosis of spermatogonia in juvenile male mice."],"pmcid":["PMC5520686"],"pubmed_authors":["Xu L","Zong S","Han R","Lu Y","Miao S","Yao R","Wang H","Li K","Wang L","Zhong S","Fu J","Luo Y","Han D","Song W"],"additional_accession":[]},"is_claimable":false,"name":"Rnf138 deficiency promotes apoptosis of spermatogonia in juvenile male mice.","description":"Spermatogenesis, the process by which haploid sperm cells are produced from a diploid precursor cell, is essential for sexual reproduction. Here, we report that RING-finger protein 138 (Rnf138) is highly expressed in testes, especially in spermatogonia and spermatocytes. The role of Rnf138 in spermatogenesis was examined using a Rnf138-knockout mouse model. Rnf138 deficiency resulted in increased apoptosis in spermatogenic cells, loss of proliferative spermatogonia, delayed development of spermatozoa and impaired fertility. The proportion of PLZF+Ki67+ cells within the PLZF+ population decreased in the knockout mice. The phenotype was further assessed by RNA-sequencing (RNA-seq), which determined that the expression levels of many genes involved in spermatogenesis were altered in the testi","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 May","modification":"2026-05-06T01:18:01.295Z","creation":"2019-03-27T00:09:04Z"},"accession":"S-EPMC5520686","cross_references":{"pubmed":["28518149"],"doi":["10.1038/cddis.2017.110"]}}