{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Racys DT"],"funding":["University of Bristol","Science and Technology Facilities Council","AstraZeneca","Engineering and Physical Sciences Research Council"],"pagination":["5793-5801"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5520773"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(10)"],"pubmed_abstract":["Under optimised conditions, the Trost modular ligand (TML) series induces high levels of asymmetric induction in an extraordinarily wide range of reactions involving palladium <i>π</i>-allyl intermediates. Prior mechanistic investigations into reactions involving Pd-<i>η</i><sup>3</sup>-C<sub>6</sub>H<sub>9</sub> intermediates have focussed on the monomeric 13-membered ring formed <i>via</i> P,P-chelation of the ligand to Pd. However, it is also recognised that ring-opening oligomerisation provides a pool of high nuclearity Pd-<i>η</i><sup>3</sup>-C<sub>6</sub>H<sub>9</sub> species that, by affording a low level, or even the opposite sense, of asymmetric induction relative to the mononuclear species, are responsible for a reduction in selectivity under non-optimised conditions. Herein we d"],"journal":["Chemical science"],"pubmed_title":["Pd- <b><i>η</i></b><sup><b>3</b></sup> -C<sub>6</sub>H<sub>9</sub> complexes of the Trost modular ligand: high nuclearity columnar aggregation controlled by concentration, solvent and counterion."],"pmcid":["PMC5520773"],"funding_grant_id":["EP/G036764/1"],"pubmed_authors":["Norrby PO","Grillo I","Lloyd-Jones GC","Rogers SE","Racys DT","Eastoe J"],"additional_accession":[]},"is_claimable":false,"name":"Pd- <b><i>η</i></b><sup><b>3</b></sup> -C<sub>6</sub>H<sub>9</sub> complexes of the Trost modular ligand: high nuclearity columnar aggregation controlled by concentration, solvent and counterion.","description":"Under optimised conditions, the Trost modular ligand (TML) series induces high levels of asymmetric induction in an extraordinarily wide range of reactions involving palladium <i>π</i>-allyl intermediates. Prior mechanistic investigations into reactions involving Pd-<i>η</i><sup>3</sup>-C<sub>6</sub>H<sub>9</sub> intermediates have focussed on the monomeric 13-membered ring formed <i>via</i> P,P-chelation of the ligand to Pd. However, it is also recognised that ring-opening oligomerisation provides a pool of high nuclearity Pd-<i>η</i><sup>3</sup>-C<sub>6</sub>H<sub>9</sub> species that, by affording a low level, or even the opposite sense, of asymmetric induction relative to the mononuclear species, are responsible for a reduction in selectivity under non-optimised conditions. Herein we d","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Oct","modification":"2025-04-05T21:12:15.893Z","creation":"2019-03-27T02:51:11Z"},"accession":"S-EPMC5520773","cross_references":{"pubmed":["28791087"],"doi":["10.1039/c5sc01181g"]}}