{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(25)"],"submitter":["Lyu X"],"pubmed_abstract":["<h4>Background</h4>Perioperative blood transfusion may be associated with negative clinical outcomes in oncological surgery. A meta-analysis of published studies was conducted to evaluate the impact of blood transfusion on short- and long-term outcomes following liver resection of colorectal liver metastasis (CLM).<h4>Materials and methods</h4>A systematic search was performed to identify relevant articles. Data were pooled for meta-analysis using Review Manager version 5.3.<h4>Results</h4>Twenty-five observational studies containing 10621 patients were subjected to the analysis. Compared with non-transfused patients, transfused patients experienced higher overall morbidity (odds ratio [OR], 1.98; 95% confidence intervals [CI] =1.49-2.33), more major complications (OR, 2.12; 95% CI =1.26-3.58), higher mortality (OR, 4.13; 95% CI =1.96-8.72), and longer length of hospital stay (weighted mean difference, 4.43; 95% CI =1.15-7.69). Transfusion was associated with reduced overall survival (risk ratio [RR], 1.24, 95% CI =1.11-1.38) and disease-free survival (RR, 1.38, 95% CI=1.23-1.56).<h4>Conclusion</h4>Perioperative blood transfusion has a detrimental impact on the clinical outcomes of patients undergoing CLM resection."],"journal":["Oncotarget"],"pagination":["41740-41748"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5522331"],"repository":["biostudies-literature"],"pubmed_title":["Impact of perioperative blood transfusion on clinical outcomes in patients with colorectal liver metastasis after hepatectomy: a meta-analysis."],"pmcid":["PMC5522331"],"pubmed_authors":["Qiao W","Li D","Lyu X","Leng Y"],"additional_accession":[]},"is_claimable":false,"name":"Impact of perioperative blood transfusion on clinical outcomes in patients with colorectal liver metastasis after hepatectomy: a meta-analysis.","description":"<h4>Background</h4>Perioperative blood transfusion may be associated with negative clinical outcomes in oncological surgery. A meta-analysis of published studies was conducted to evaluate the impact of blood transfusion on short- and long-term outcomes following liver resection of colorectal liver metastasis (CLM).<h4>Materials and methods</h4>A systematic search was performed to identify relevant articles. Data were pooled for meta-analysis using Review Manager version 5.3.<h4>Results</h4>Twenty-five observational studies containing 10621 patients were subjected to the analysis. Compared with non-transfused patients, transfused patients experienced higher overall morbidity (odds ratio [OR], 1.98; 95% confidence intervals [CI] =1.49-2.33), more major complications (OR, 2.12; 95% CI =1.26-3.58), higher mortality (OR, 4.13; 95% CI =1.96-8.72), and longer length of hospital stay (weighted mean difference, 4.43; 95% CI =1.15-7.69). Transfusion was associated with reduced overall survival (risk ratio [RR], 1.24, 95% CI =1.11-1.38) and disease-free survival (RR, 1.38, 95% CI=1.23-1.56).<h4>Conclusion</h4>Perioperative blood transfusion has a detrimental impact on the clinical outcomes of patients undergoing CLM resection.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jun","modification":"2025-04-04T20:53:54.12Z","creation":"2019-03-27T02:51:18Z"},"accession":"S-EPMC5522331","cross_references":{"pubmed":["28410243"],"doi":["10.18632/oncotarget.16771"]}}