biostudies-literatureUnknown8(25)Lyu X<h4>Background</h4>Perioperative blood transfusion may be associated with negative clinical outcomes in oncological surgery. A meta-analysis of published studies was conducted to evaluate the impact of blood transfusion on short- and long-term outcomes following liver resection of colorectal liver metastasis (CLM).<h4>Materials and methods</h4>A systematic search was performed to identify relevant articles. Data were pooled for meta-analysis using Review Manager version 5.3.<h4>Results</h4>Twenty-five observational studies containing 10621 patients were subjected to the analysis. Compared with non-transfused patients, transfused patients experienced higher overall morbidity (odds ratio [OR], 1.98; 95% confidence intervals [CI] =1.49-2.33), more major complications (OR, 2.12; 95% CI =1.26-3.58), higher mortality (OR, 4.13; 95% CI =1.96-8.72), and longer length of hospital stay (weighted mean difference, 4.43; 95% CI =1.15-7.69). Transfusion was associated with reduced overall survival (risk ratio [RR], 1.24, 95% CI =1.11-1.38) and disease-free survival (RR, 1.38, 95% CI=1.23-1.56).<h4>Conclusion</h4>Perioperative blood transfusion has a detrimental impact on the clinical outcomes of patients undergoing CLM resection.Oncotarget41740-41748https://www.ebi.ac.uk/biostudies/studies/S-EPMC5522331biostudies-literatureImpact of perioperative blood transfusion on clinical outcomes in patients with colorectal liver metastasis after hepatectomy: a meta-analysis.PMC5522331Qiao WLi DLyu XLeng YfalseImpact of perioperative blood transfusion on clinical outcomes in patients with colorectal liver metastasis after hepatectomy: a meta-analysis.<h4>Background</h4>Perioperative blood transfusion may be associated with negative clinical outcomes in oncological surgery. A meta-analysis of published studies was conducted to evaluate the impact of blood transfusion on short- and long-term outcomes following liver resection of colorectal liver metastasis (CLM).<h4>Materials and methods</h4>A systematic search was performed to identify relevant articles. Data were pooled for meta-analysis using Review Manager version 5.3.<h4>Results</h4>Twenty-five observational studies containing 10621 patients were subjected to the analysis. Compared with non-transfused patients, transfused patients experienced higher overall morbidity (odds ratio [OR], 1.98; 95% confidence intervals [CI] =1.49-2.33), more major complications (OR, 2.12; 95% CI =1.26-3.58), higher mortality (OR, 4.13; 95% CI =1.96-8.72), and longer length of hospital stay (weighted mean difference, 4.43; 95% CI =1.15-7.69). Transfusion was associated with reduced overall survival (risk ratio [RR], 1.24, 95% CI =1.11-1.38) and disease-free survival (RR, 1.38, 95% CI=1.23-1.56).<h4>Conclusion</h4>Perioperative blood transfusion has a detrimental impact on the clinical outcomes of patients undergoing CLM resection.2017-01-01T00:00:00Z2017 Jun2025-04-04T20:53:54.12Z2019-03-27T02:51:18ZS-EPMC55223312841024310.18632/oncotarget.16771