{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["59(2)"],"submitter":["Bellanti F"],"pubmed_abstract":["A disruption to circadian rhythmicity and the sleep/wake cycle constitutes a major feature of Alzheimer's disease (AD). The maintenance of circadian rhythmicity is regulated by endogenous clock genes and a number of external Zeitgebers, including light. This study investigated the light induced changes in the expression of clock genes in a triple transgenic model of AD (3×Tg-AD) and their wild type littermates (Non-Tg). Changes in gene expression were evaluated in four brain areas¾suprachiasmatic nucleus (SCN), hippocampus, frontal cortex and brainstem¾of 6- and 18-month-old Non-Tg and 3×Tg-AD mice after 12 h exposure to light or darkness. Light exposure exerted significant effects on clock gene expression in the SCN, the site of the major circadian pacemaker. These patterns of expression "],"journal":["Journal of Alzheimer's disease : JAD"],"pagination":["615-631"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5523844"],"repository":["biostudies-literature"],"pubmed_title":["Alterations of Clock Gene RNA Expression in Brain Regions of a Triple Transgenic Model of Alzheimer's Disease."],"pmcid":["PMC5523844"],"pubmed_authors":["Vendemiale G","Mazzoccoli G","Blonda M","Tamborra R","Serviddio G","Romano A","Iannelli G","Bellanti F","Villani R","Giudetti AM","Cassano T","Calcagnini S","Gaetani S","Vinciguerra M"],"additional_accession":[]},"is_claimable":false,"name":"Alterations of Clock Gene RNA Expression in Brain Regions of a Triple Transgenic Model of Alzheimer's Disease.","description":"A disruption to circadian rhythmicity and the sleep/wake cycle constitutes a major feature of Alzheimer's disease (AD). The maintenance of circadian rhythmicity is regulated by endogenous clock genes and a number of external Zeitgebers, including light. This study investigated the light induced changes in the expression of clock genes in a triple transgenic model of AD (3×Tg-AD) and their wild type littermates (Non-Tg). Changes in gene expression were evaluated in four brain areas¾suprachiasmatic nucleus (SCN), hippocampus, frontal cortex and brainstem¾of 6- and 18-month-old Non-Tg and 3×Tg-AD mice after 12 h exposure to light or darkness. Light exposure exerted significant effects on clock gene expression in the SCN, the site of the major circadian pacemaker. These patterns of expression ","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2025-07-24T03:04:35.335Z","creation":"2025-07-24T03:04:35.335Z"},"accession":"S-EPMC5523844","cross_references":{"pubmed":["28671110"],"doi":["10.3233/JAD-160942"]}}