{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(1)"],"submitter":["da Silva IL"],"pubmed_abstract":["Qa-2 is believed to mediate a protective immune response against cancer; however, little is known about the role of Qa-2 in tumorigenesis. Here, we used 4T1 breast cancer cells to study the involvement of Qa-2 in tumor progression in a syngeneic host. Qa-2 expression was reduced during in vivo tumor growth and in cell lines derived from 4T1-induced tumors. Tumor-derived cells elicited an epithelial-mesenchymal transition associated with upregulation of Zeb1 and Twist1/2 and enhanced tumor initiating and invasive capacities. Furthermore, these cells showed increased stem characteristics, as demonstrated by upregulation of Hes1, Sox2 and Oct3/4, and enrichment of CD44<sup>high</sup>/CD24<sup>median/low</sup> cells. Remarkably, Qa-2 cell-surface expression was excluded from the CD44<sup>high<"],"journal":["Scientific reports"],"pagination":["6276"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5524840"],"repository":["biostudies-literature"],"pubmed_title":["Reduced expression of the murine HLA-G homolog Qa-2 is associated with malignancy, epithelial-mesenchymal transition and stemness in breast cancer cells."],"pmcid":["PMC5524840"],"pubmed_authors":["Ferreira E","Toscano Simoes R","de Oliveira MC","Renart J","Soares Veloso E","Salviano Teixeira C","Martin-Villar E","Quintanilla M","Montero-Montero L","da Silva IL","Martin-Perez J","Sainz B"],"additional_accession":[]},"is_claimable":false,"name":"Reduced expression of the murine HLA-G homolog Qa-2 is associated with malignancy, epithelial-mesenchymal transition and stemness in breast cancer cells.","description":"Qa-2 is believed to mediate a protective immune response against cancer; however, little is known about the role of Qa-2 in tumorigenesis. Here, we used 4T1 breast cancer cells to study the involvement of Qa-2 in tumor progression in a syngeneic host. Qa-2 expression was reduced during in vivo tumor growth and in cell lines derived from 4T1-induced tumors. Tumor-derived cells elicited an epithelial-mesenchymal transition associated with upregulation of Zeb1 and Twist1/2 and enhanced tumor initiating and invasive capacities. Furthermore, these cells showed increased stem characteristics, as demonstrated by upregulation of Hes1, Sox2 and Oct3/4, and enrichment of CD44<sup>high</sup>/CD24<sup>median/low</sup> cells. Remarkably, Qa-2 cell-surface expression was excluded from the CD44<sup>high<","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jul","modification":"2025-06-01T01:39:25.04Z","creation":"2025-06-01T01:39:25.04Z"},"accession":"S-EPMC5524840","cross_references":{"pubmed":["28740236"],"doi":["10.1038/s41598-017-06528-x"]}}