{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee HJ"],"funding":["NIBIB NIH HHS","NIA NIH HHS","NINDS NIH HHS","NIH HHS"],"pagination":["412-24"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5528162"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["91(2)"],"pubmed_abstract":["A central theory of basal ganglia function is that striatal neurons expressing the D1 and D2 dopamine receptors exert opposing brain-wide influences. However, the causal influence of each population has never been measured at the whole-brain scale. Here, we selectively stimulated D1 or D2 receptor-expressing neurons while visualizing whole-brain activity with fMRI. Excitation of either inhibitory population evoked robust positive BOLD signals within striatum, while downstream regions exhibited significantly different and generally opposing responses consistent with-though not easily predicted from-contemporary models of basal ganglia function. Importantly, positive and negative signals within the striatum, thalamus, GPi, and STN were all associated with increases and decreases in single-un"],"journal":["Neuron"],"pubmed_title":["Activation of Direct and Indirect Pathway Medium Spiny Neurons Drives Distinct Brain-wide Responses."],"pmcid":["PMC5528162"],"funding_grant_id":["DP2 OD007265","R00 EB008738","R01 NS091461","R01 NS087159","R01 NS064984","RF1 AG047666"],"pubmed_authors":["Kreitzer AC","Kravitz AV","Bernal-Casas D","Lee HJ","Weitz AJ","Duffy BA","Choy M","Lee JH"],"additional_accession":[]},"is_claimable":false,"name":"Activation of Direct and Indirect Pathway Medium Spiny Neurons Drives Distinct Brain-wide Responses.","description":"A central theory of basal ganglia function is that striatal neurons expressing the D1 and D2 dopamine receptors exert opposing brain-wide influences. However, the causal influence of each population has never been measured at the whole-brain scale. Here, we selectively stimulated D1 or D2 receptor-expressing neurons while visualizing whole-brain activity with fMRI. Excitation of either inhibitory population evoked robust positive BOLD signals within striatum, while downstream regions exhibited significantly different and generally opposing responses consistent with-though not easily predicted from-contemporary models of basal ganglia function. Importantly, positive and negative signals within the striatum, thalamus, GPi, and STN were all associated with increases and decreases in single-un","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jul","modification":"2026-05-05T20:46:37.901Z","creation":"2019-03-27T02:51:41Z"},"accession":"S-EPMC5528162","cross_references":{"pubmed":["27373834"],"doi":["10.1016/j.neuron.2016.06.010"]}}