{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Massink MP"],"funding":["Netherlands Genomics Initiative/Netherlands Organization for Scientific Research NWO"],"pagination":["877-88"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5528776"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(4)"],"pubmed_abstract":["<h4>Introduction</h4>BRCA1-mutated breast carcinomas may have distinct biological features, suggesting the involvement of specific oncogenic pathways in tumor development. The identification of genomic aberrations characteristic for BRCA1-mutated breast carcinomas could lead to a better understanding of BRCA1-associated oncogenic events and could prove valuable in clinical testing for BRCA1-involvement in patients.<h4>Methods</h4>For this purpose, genomic and gene expression profiles of basal-like BRCA1-mutated breast tumors (n = 27) were compared with basal-like familial BRCAX (non-BRCA1/2/CHEK2*1100delC) tumors (n = 14) in a familial cohort of 120 breast carcinomas.<h4>Results</h4>Genome wide copy number profiles of the BRCA1-mutated breast carcinomas in our data appeared heterogeneous. "],"journal":["Molecular oncology"],"pubmed_title":["Proper genomic profiling of (BRCA1-mutated) basal-like breast carcinomas requires prior removal of tumor infiltrating lymphocytes."],"pmcid":["PMC5528776"],"funding_grant_id":["91756341"],"pubmed_authors":["Dorsman JC","van Dyk E","Nederlof PM","van Beek DM","Martens JW","Sieuwerts AM","van der Voorn JP","Meijers-Heijboer H","van Mil SE","van den Ouweland AM","Ameziane N","Sie D","Smid M","de Weerd V","Foekens JA","van Deurzen CH","Massink MP","Kooi IE","Waisfisz Q","Ylstra B","Jordanova ES"],"additional_accession":[]},"is_claimable":false,"name":"Proper genomic profiling of (BRCA1-mutated) basal-like breast carcinomas requires prior removal of tumor infiltrating lymphocytes.","description":"<h4>Introduction</h4>BRCA1-mutated breast carcinomas may have distinct biological features, suggesting the involvement of specific oncogenic pathways in tumor development. The identification of genomic aberrations characteristic for BRCA1-mutated breast carcinomas could lead to a better understanding of BRCA1-associated oncogenic events and could prove valuable in clinical testing for BRCA1-involvement in patients.<h4>Methods</h4>For this purpose, genomic and gene expression profiles of basal-like BRCA1-mutated breast tumors (n = 27) were compared with basal-like familial BRCAX (non-BRCA1/2/CHEK2*1100delC) tumors (n = 14) in a familial cohort of 120 breast carcinomas.<h4>Results</h4>Genome wide copy number profiles of the BRCA1-mutated breast carcinomas in our data appeared heterogeneous. ","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Apr","modification":"2025-04-05T15:13:08.068Z","creation":"2019-03-27T02:51:44Z"},"accession":"S-EPMC5528776","cross_references":{"pubmed":["25616998"],"doi":["10.1016/j.molonc.2014.12.012"]}}