biostudies-literatureMassink MPNetherlands Genomics Initiative/Netherlands Organization for Scientific Research NWO877-88https://www.ebi.ac.uk/biostudies/studies/S-EPMC5528776biostudies-literatureUnknown9(4)<h4>Introduction</h4>BRCA1-mutated breast carcinomas may have distinct biological features, suggesting the involvement of specific oncogenic pathways in tumor development. The identification of genomic aberrations characteristic for BRCA1-mutated breast carcinomas could lead to a better understanding of BRCA1-associated oncogenic events and could prove valuable in clinical testing for BRCA1-involvement in patients.<h4>Methods</h4>For this purpose, genomic and gene expression profiles of basal-like BRCA1-mutated breast tumors (n = 27) were compared with basal-like familial BRCAX (non-BRCA1/2/CHEK2*1100delC) tumors (n = 14) in a familial cohort of 120 breast carcinomas.<h4>Results</h4>Genome wide copy number profiles of the BRCA1-mutated breast carcinomas in our data appeared heterogeneous. Molecular oncologyProper genomic profiling of (BRCA1-mutated) basal-like breast carcinomas requires prior removal of tumor infiltrating lymphocytes.PMC552877691756341Dorsman JCvan Dyk ENederlof PMvan Beek DMMartens JWSieuwerts AMvan der Voorn JPMeijers-Heijboer Hvan Mil SEvan den Ouweland AMAmeziane NSie DSmid Mde Weerd VFoekens JAvan Deurzen CHMassink MPKooi IEWaisfisz QYlstra BJordanova ESfalseProper genomic profiling of (BRCA1-mutated) basal-like breast carcinomas requires prior removal of tumor infiltrating lymphocytes.<h4>Introduction</h4>BRCA1-mutated breast carcinomas may have distinct biological features, suggesting the involvement of specific oncogenic pathways in tumor development. The identification of genomic aberrations characteristic for BRCA1-mutated breast carcinomas could lead to a better understanding of BRCA1-associated oncogenic events and could prove valuable in clinical testing for BRCA1-involvement in patients.<h4>Methods</h4>For this purpose, genomic and gene expression profiles of basal-like BRCA1-mutated breast tumors (n = 27) were compared with basal-like familial BRCAX (non-BRCA1/2/CHEK2*1100delC) tumors (n = 14) in a familial cohort of 120 breast carcinomas.<h4>Results</h4>Genome wide copy number profiles of the BRCA1-mutated breast carcinomas in our data appeared heterogeneous. 2015-01-01T00:00:00Z2015 Apr2025-04-05T15:13:08.068Z2019-03-27T02:51:44ZS-EPMC55287762561699810.1016/j.molonc.2014.12.012