{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(1)"],"submitter":["Diao X"],"pubmed_abstract":["Osseointegration is the key to implant stability and occlusal support. Biomechanical response and remodeling of peri-implant bone occurs under impact loading. Sclerostin participates in bone formation and resorption through Wnt and RANKL pathways. However the mechanism of microdamage and expression of sclerostin in peri-implant bone under impact load is still unclear. In present study, specific impact forces were applied to the implants with favorable osseointegration in rabbits. The microdamage of peri-implant bone and the expression of sclerostin, β-catenin and RANKL during the process of bone damage and remodeling were investigated by micro-CT, histology, immunofluorescence and RT-qPCR analysis. Interface separation and trabecular fracture were found histologically, which were consisten"],"journal":["Scientific reports"],"pagination":["6508"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5529451"],"repository":["biostudies-literature"],"pubmed_title":["The Microdamage and Expression of Sclerostin in Peri-implant Bone under One-time Shock Force Generated by Impact."],"pmcid":["PMC5529451"],"pubmed_authors":["An B","Li Z","Diao X","Feng F","Xin H","Li K","Wu Y","Dou C"],"additional_accession":[]},"is_claimable":false,"name":"The Microdamage and Expression of Sclerostin in Peri-implant Bone under One-time Shock Force Generated by Impact.","description":"Osseointegration is the key to implant stability and occlusal support. Biomechanical response and remodeling of peri-implant bone occurs under impact loading. Sclerostin participates in bone formation and resorption through Wnt and RANKL pathways. However the mechanism of microdamage and expression of sclerostin in peri-implant bone under impact load is still unclear. In present study, specific impact forces were applied to the implants with favorable osseointegration in rabbits. The microdamage of peri-implant bone and the expression of sclerostin, β-catenin and RANKL during the process of bone damage and remodeling were investigated by micro-CT, histology, immunofluorescence and RT-qPCR analysis. Interface separation and trabecular fracture were found histologically, which were consisten","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jul","modification":"2025-04-04T12:50:06.37Z","creation":"2019-03-27T02:51:47Z"},"accession":"S-EPMC5529451","cross_references":{"pubmed":["28747741"],"doi":["10.1038/s41598-017-06867-9"]}}