biostudies-literatureUnknown7(1)Diao XOsseointegration is the key to implant stability and occlusal support. Biomechanical response and remodeling of peri-implant bone occurs under impact loading. Sclerostin participates in bone formation and resorption through Wnt and RANKL pathways. However the mechanism of microdamage and expression of sclerostin in peri-implant bone under impact load is still unclear. In present study, specific impact forces were applied to the implants with favorable osseointegration in rabbits. The microdamage of peri-implant bone and the expression of sclerostin, β-catenin and RANKL during the process of bone damage and remodeling were investigated by micro-CT, histology, immunofluorescence and RT-qPCR analysis. Interface separation and trabecular fracture were found histologically, which were consistenScientific reports6508https://www.ebi.ac.uk/biostudies/studies/S-EPMC5529451biostudies-literatureThe Microdamage and Expression of Sclerostin in Peri-implant Bone under One-time Shock Force Generated by Impact.PMC5529451An BLi ZDiao XFeng FXin HLi KWu YDou CfalseThe Microdamage and Expression of Sclerostin in Peri-implant Bone under One-time Shock Force Generated by Impact.Osseointegration is the key to implant stability and occlusal support. Biomechanical response and remodeling of peri-implant bone occurs under impact loading. Sclerostin participates in bone formation and resorption through Wnt and RANKL pathways. However the mechanism of microdamage and expression of sclerostin in peri-implant bone under impact load is still unclear. In present study, specific impact forces were applied to the implants with favorable osseointegration in rabbits. The microdamage of peri-implant bone and the expression of sclerostin, β-catenin and RANKL during the process of bone damage and remodeling were investigated by micro-CT, histology, immunofluorescence and RT-qPCR analysis. Interface separation and trabecular fracture were found histologically, which were consisten2017-01-01T00:00:00Z2017 Jul2025-04-04T12:50:06.37Z2019-03-27T02:51:47ZS-EPMC55294512874774110.1038/s41598-017-06867-9