{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Betts MR"],"funding":["NIAID NIH HHS","Medical Research Council"],"pagination":["4512-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC552973"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["102(12)"],"pubmed_abstract":["Worldwide HIV-1 vaccine efforts are guided by the principle that HIV-specific T cell responses may provide protection from infection or delay overt disease. However, no clear correlates of T cell-mediated immune protection have been identified. Here, we examine in a HLA-B27(+) HIV seronegative vaccinee persistent HIV-specific vaccine-induced anti-Gag CD4(+) and CD8(+) T cell responses. Although these responses exhibited those characteristics (multifunctionality, appropriate memory phenotype, and targeting of epitopes associated with long-term nonprogression) predicted to correlate with protection from infection, the subject became HIV infected. After HIV infection, the vaccine-induced CD8(+) T cells expanded, but both CD4(+) and CD8(+) T cell responses acquired the functional and phenotypi"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection."],"pmcid":["PMC552973"],"funding_grant_id":["5T32 AI07392","5U01-AI46725","T32 AI007392","U01 AI046725","3P30-AI28662","5R01-AI50483","U01-AI41530","R01 AI050483","G108/441","R01-AI49126","R01 AI049126","U01 AI041530"],"pubmed_authors":["Tomaras G","Roederer M","Douek DC","Price DA","Ambrozak DR","Ferrari G","West SM","Belshe R","Goepfert P","Gao F","Kilby JM","Bansal A","Koup RA","Betts MR","Exley B","Weinhold KJ","Tartaglia J","Camacho ZT","Teaberry V"],"additional_accession":[]},"is_claimable":false,"name":"Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection.","description":"Worldwide HIV-1 vaccine efforts are guided by the principle that HIV-specific T cell responses may provide protection from infection or delay overt disease. However, no clear correlates of T cell-mediated immune protection have been identified. Here, we examine in a HLA-B27(+) HIV seronegative vaccinee persistent HIV-specific vaccine-induced anti-Gag CD4(+) and CD8(+) T cell responses. Although these responses exhibited those characteristics (multifunctionality, appropriate memory phenotype, and targeting of epitopes associated with long-term nonprogression) predicted to correlate with protection from infection, the subject became HIV infected. After HIV infection, the vaccine-induced CD8(+) T cells expanded, but both CD4(+) and CD8(+) T cell responses acquired the functional and phenotypi","dates":{"release":"2005-01-01T00:00:00Z","publication":"2005 Mar","modification":"2026-05-02T22:14:01.077Z","creation":"2019-03-27T01:08:38Z"},"accession":"S-EPMC552973","cross_references":{"pubmed":["15753288"],"doi":["10.1073/pnas.0408773102"]}}