biostudies-literatureWilliams MCBritish Heart FoundationMedical Research CouncilChief Scientist OfficeHealth Research BoardWellcome Trust995-1001https://www.ebi.ac.uk/biostudies/studies/S-EPMC5529983biostudies-literatureUnknown103(13)<h4>Background</h4>In patients with suspected angina pectoris, CT coronary angiography (CTCA) clarifies the diagnosis, directs appropriate investigations and therapies, and reduces clinical events. The effect on patient symptoms is currently unknown.<h4>Methods</h4>In a prospective open-label parallel group multicentre randomised controlled trial, 4146 patients with suspected angina due to coronary heart disease were randomised 1:1 to receive standard care or standard care plus CTCA. Symptoms and quality of life were assessed over 6 months using the Seattle Angina Questionnaire and Short Form 12.<h4>Results</h4>Baseline scores indicated mild physical limitation (74±0.4), moderate angina stability (44±0.4), modest angina frequency (68±0.4), excellent treatment satisfaction (92±0.2) and modeHeart (British Cardiac Society)Symptoms and quality of life in patients with suspected angina undergoing CT coronary angiography: a randomised controlled trial.PMC5529983G0701127103782/Z/14/ZCZH/4/588FS/16/14/32023MR/N003403/1RL-2013-11Williams MRitchie VPerkins SClarkin PPaterson VWackett ALeslie SClark EFlint LPrasad GRHunter ALetham DTaylor FAhmed FSteedman TWeir-McCall JCrawford WRae AMorrison AAssi VShepherd SNeary PMurphy CHargreaves ABoylan HMcGlynn DBloomfield PForbes JWeir NDougherty FMcGowan JCruden NGrubb NConnolly EHouston GMordi IHood SPringle SWhite TMcLennan EDweck MBrian DBoon NAUren NNorthridge DFindlay IHall FTeenan MDawson AMcLean SBehan MWee FDivers FRoditi GGlen STeyhan FHenriksen PWoodward RPeat EAllen BMurdoch LNewby DEKeanie CMacLachlan DMangion KLennon EHenry MDougall HRobb KBrown AO'Neill LOatey KBissett KDinnel LEteiba HLang CQueripel LBarlow TFowler JGlover CCormack ABertram DMcKillop GJacob AMirsadraee SMcCubbin Mvan Beek EJParker RCairns ACowan APawade TMacLeod DFairley KSandeman DBerry CMacLeod MLewis SKeegan ECram LFogarty YFlapan AMcGregor LMills NDenvir MMacGillivray TScottish COmputed Tomography of the HEART (SCOT-HEART) Trial InvestigatorsKrishan AMilne LFlather MSpratt JMcCormack CTzemos NBeveridge CFarrell LCraig PFrancis MBarrie DWalker ATimmis ADPhillips AWilliams MCBucukoglu MDundas SLanaghan KGemmill JSudarshan TFyfe SFotheringham MFairbairn TBett FShah AJohnstone JReid JFrood ADonaldson GMcCabe LfalseSymptoms and quality of life in patients with suspected angina undergoing CT coronary angiography: a randomised controlled trial.<h4>Background</h4>In patients with suspected angina pectoris, CT coronary angiography (CTCA) clarifies the diagnosis, directs appropriate investigations and therapies, and reduces clinical events. The effect on patient symptoms is currently unknown.<h4>Methods</h4>In a prospective open-label parallel group multicentre randomised controlled trial, 4146 patients with suspected angina due to coronary heart disease were randomised 1:1 to receive standard care or standard care plus CTCA. Symptoms and quality of life were assessed over 6 months using the Seattle Angina Questionnaire and Short Form 12.<h4>Results</h4>Baseline scores indicated mild physical limitation (74±0.4), moderate angina stability (44±0.4), modest angina frequency (68±0.4), excellent treatment satisfaction (92±0.2) and mode2017-01-01T00:00:00Z2017 Jul2026-06-17T06:13:59.614Z2026-06-17T03:07:17.256ZS-EPMC55299832824617510.1136/heartjnl-2016-310129