{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["80(2)"],"submitter":["Netterberg I"],"funding":["Cancerfonden (SE)"],"pubmed_abstract":["<h4>Purpose</h4>To investigate whether a more frequent monitoring of the absolute neutrophil counts (ANC) during myelosuppressive chemotherapy, together with model-based predictions, can improve therapy management, compared to the limited clinical monitoring typically applied today.<h4>Methods</h4>Daily ANC in chemotherapy-treated cancer patients were simulated from a previously published population model describing docetaxel-induced myelosuppression. The simulated values were used to generate predictions of the individual ANC time-courses, given the myelosuppression model. The accuracy of the predicted ANC was evaluated under a range of conditions with reduced amount of ANC measurements.<h4>Results</h4>The predictions were most accurate when more data were available for generating the pre"],"journal":["Cancer chemotherapy and pharmacology"],"pagination":["343-353"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5532422"],"repository":["biostudies-literature"],"pubmed_title":["Model-based prediction of myelosuppression and recovery based on frequent neutrophil monitoring."],"pmcid":["PMC5532422"],"pubmed_authors":["Nielsen EI","Netterberg I","Karlsson MO","Friberg LE"],"additional_accession":[]},"is_claimable":false,"name":"Model-based prediction of myelosuppression and recovery based on frequent neutrophil monitoring.","description":"<h4>Purpose</h4>To investigate whether a more frequent monitoring of the absolute neutrophil counts (ANC) during myelosuppressive chemotherapy, together with model-based predictions, can improve therapy management, compared to the limited clinical monitoring typically applied today.<h4>Methods</h4>Daily ANC in chemotherapy-treated cancer patients were simulated from a previously published population model describing docetaxel-induced myelosuppression. The simulated values were used to generate predictions of the individual ANC time-courses, given the myelosuppression model. The accuracy of the predicted ANC was evaluated under a range of conditions with reduced amount of ANC measurements.<h4>Results</h4>The predictions were most accurate when more data were available for generating the pre","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Aug","modification":"2025-05-31T23:31:39.049Z","creation":"2025-05-31T23:31:39.049Z"},"accession":"S-EPMC5532422","cross_references":{"pubmed":["28656382"],"doi":["10.1007/s00280-017-3366-x"]}}