{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Blauwendraat C"],"funding":["National Institute of Neurological Disorders and Stroke","National Institute of Environmental Health Sciences","Intramural NIH HHS","Bundesministerium für Bildung und Forschung","Parkinson's UK","National Institutes of Health","National Institute of General Medical Sciences","National Institute on Aging","Huffington Foundation","EU Joint Programme – Neurodegenerative Disease Research","Barts Charity","U.S. Department of Health and Human Services","Burroughs Wellcome Fund","Medical Research Council","National Institute for Health Research (NIHR)","Muscular Dystrophy UK","Parkinson's UK"],"pagination":["247.e9-247.e13"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5534378"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["57"],"pubmed_abstract":["Genetics has proven to be a powerful approach in neurodegenerative diseases research, resulting in the identification of numerous causal and risk variants. Previously, we introduced the NeuroX Illumina genotyping array, a fast and efficient genotyping platform designed for the investigation of genetic variation in neurodegenerative diseases. Here, we present its updated version, named NeuroChip. The NeuroChip is a low-cost, custom-designed array containing a tagging variant backbone of about 306,670 variants complemented with a manually curated custom content comprised of 179,467 variants implicated in diverse neurological diseases, including Alzheimer's disease, Parkinson's disease, Lewy body dementia, amyotrophic lateral sclerosis, frontotemporal dementia, progressive supranuclear palsy,"],"journal":["Neurobiology of aging"],"pubmed_title":["NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases."],"pmcid":["PMC5534378"],"funding_grant_id":["Z99 NS999999","NF-SI-0515-10082","Z01 AG000949","MR/L501554/1","MR/K01417X/1","MGU0364","G0300429","G-1107","G0802462","MR/N008324/1","G0700943","8047","Z01-AG000949-02","NF-SI-0507-10376","16GRO-PS36-0055","MC_PC_09003","K-1501","ACF-2012-17-017","MR/L023784/2","G1100643","MR/L023784/1","1U54GM114838","ZIA NS003154","NF-SI-0513-10064","J-0804","Z01 ES101986","1ZIANS003154","Z01-ES101986"],"pubmed_authors":["Robak L","Pihlstrom L","Geiger JT","Williams J","Campbell RH","Ryten M","Hernandez DG","Murphy NA","Gasser T","Lesage S","Guerreiro R","Blauwendraat C","International Parkinson's Disease Genomics Consortium (IPDGC), COURAGE-PD Consortium","Wood NW","Sims R","Chung SJ","Bras J","Faghri F","Hardy JA","Lubbe S","May P","Nicolas A","Gibbs JR","Houlden H","Rogaeva E","Ferrari R","Singleton AB","Brice A","Shulman JM","Heutink P","Simon-Sanchez J","Sharma M","Chia R","Traynor BJ","Abramzon Y","Corvol JC","Mok KY","Kruger R","Elbaz A","Morris HR","Nalls MA","Scholz SW"],"additional_accession":[]},"is_claimable":false,"name":"NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases.","description":"Genetics has proven to be a powerful approach in neurodegenerative diseases research, resulting in the identification of numerous causal and risk variants. Previously, we introduced the NeuroX Illumina genotyping array, a fast and efficient genotyping platform designed for the investigation of genetic variation in neurodegenerative diseases. Here, we present its updated version, named NeuroChip. The NeuroChip is a low-cost, custom-designed array containing a tagging variant backbone of about 306,670 variants complemented with a manually curated custom content comprised of 179,467 variants implicated in diverse neurological diseases, including Alzheimer's disease, Parkinson's disease, Lewy body dementia, amyotrophic lateral sclerosis, frontotemporal dementia, progressive supranuclear palsy,","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Sep","modification":"2026-05-02T09:11:37.702Z","creation":"2019-03-26T23:53:51Z"},"accession":"S-EPMC5534378","cross_references":{"pubmed":["28602509"],"doi":["10.1016/j.neurobiolaging.2017.05.009"]}}