{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":62,"searchCount":0},"additional":{"submitter":["Wu Y"],"funding":["NIGMS NIH HHS"],"pagination":["14554-14557"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5535771"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["138(44)"],"pubmed_abstract":["Pd(II)-catalyzed ?-C(sp3)-H arylation of primary amines is realized by using 2-hydroxynicotinaldehyde as a catalytic transient directing group. Importantly, the catalyst and the directing group loading can be lowered to 2% and 4% respectively, thus demonstrating high efficiency of this newly designed transient directing group. Heterocyclic aryl iodides are also compatible with this reaction. Furthermore, swift synthesis of 1,2,3,4-tetrahydronaphthyridine derivatives is accomplished using this reaction."],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Pd-Catalyzed ?-C(sp3)-H Arylation of Free Amines Using a Transient Directing Group."],"pmcid":["PMC5535771"],"funding_grant_id":["R01 GM084019"],"pubmed_authors":["Yu JQ","Chen YQ","Eastgate MD","Liu T","Wu Y"],"view_count":["62"],"additional_accession":[]},"is_claimable":false,"name":"Pd-Catalyzed ?-C(sp3)-H Arylation of Free Amines Using a Transient Directing Group.","description":"Pd(II)-catalyzed ?-C(sp3)-H arylation of primary amines is realized by using 2-hydroxynicotinaldehyde as a catalytic transient directing group. Importantly, the catalyst and the directing group loading can be lowered to 2% and 4% respectively, thus demonstrating high efficiency of this newly designed transient directing group. Heterocyclic aryl iodides are also compatible with this reaction. Furthermore, swift synthesis of 1,2,3,4-tetrahydronaphthyridine derivatives is accomplished using this reaction.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Nov","modification":"2020-11-01T08:27:18Z","creation":"2019-03-27T02:52:07Z"},"accession":"S-EPMC5535771","cross_references":{"pubmed":["27786439"],"doi":["10.1021/jacs.6b09653"]}}