{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kaur P"],"funding":["NIGMS NIH HHS"],"pagination":["6934"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5537288"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(1)"],"pubmed_abstract":["The highly conserved Wnt signaling pathway regulates cell proliferation and differentiation in vertebrates and invertebrates. Upon binding of a Wnt ligand to a receptor of the Fz family, Disheveled (Dsh/Dvl) transduces the signal during canonical and non-canonical Wnt signaling. The specific details of how this process occurs have proven difficult to study, especially as Dsh appears to function as a switch between different branches of Wnt signaling. Here we focus on the membrane-proximal events that occur once Dsh is recruited to the membrane. We show that membrane-tethering of the Dsh protein is sufficient to induce canonical Wnt signaling activation even in the absence of the Wnt co-receptor Arrow/LRP5/6. We map the protein domains required for pathway activation in membrane tethered co"],"journal":["Scientific reports"],"pubmed_title":["Membrane Targeting of Disheveled Can Bypass the Need for Arrow/LRP5."],"pmcid":["PMC5537288"],"funding_grant_id":["R01 GM115646"],"pubmed_authors":["Tolwinski NS","Jenny A","Kaur P","Mannava AG","Suresh J","Lam VYM"],"additional_accession":[]},"is_claimable":false,"name":"Membrane Targeting of Disheveled Can Bypass the Need for Arrow/LRP5.","description":"The highly conserved Wnt signaling pathway regulates cell proliferation and differentiation in vertebrates and invertebrates. Upon binding of a Wnt ligand to a receptor of the Fz family, Disheveled (Dsh/Dvl) transduces the signal during canonical and non-canonical Wnt signaling. The specific details of how this process occurs have proven difficult to study, especially as Dsh appears to function as a switch between different branches of Wnt signaling. Here we focus on the membrane-proximal events that occur once Dsh is recruited to the membrane. We show that membrane-tethering of the Dsh protein is sufficient to induce canonical Wnt signaling activation even in the absence of the Wnt co-receptor Arrow/LRP5/6. We map the protein domains required for pathway activation in membrane tethered co","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jul","modification":"2025-06-01T02:53:16.901Z","creation":"2025-06-01T02:53:16.901Z"},"accession":"S-EPMC5537288","cross_references":{"pubmed":["28761148"],"doi":["10.1038/s41598-017-04414-0"]}}