{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(7)"],"submitter":["O'Riordan N"],"pubmed_abstract":["Bovine lactoferrin (LF) has been shown to prevent adhesion to and invasion of mammalian cell lines by pathogenic bacteria, with evidence for direct bacterial binding by the milk glycoprotein. However, the glycosylation pattern of LF changes over the lactation cycle. In this study, we aim to investigate the effect that this variation has on the milk glycoprotein's ability to interact with pathogens. Surface plasmon resonance technology was employed to compare the binding of LF from colostrum (early lactation) and mature milk (late lactation) to a panel of pathogenic bacteria (Staphylococcus aureus, Escherichia coli, Cronobacter sakazakii, Streptococcus pneumoniae, Pseudomonas aeruginosa, Listeria monocytogenes and Salmonella typhimurium). Novel interactions with LF were identified for C. sa"],"journal":["Sensors (Basel, Switzerland)"],"pagination":["E1515"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5539864"],"repository":["biostudies-literature"],"pubmed_title":["Exploitation of SPR to Investigate the Importance of Glycan Chains in the Interaction between Lactoferrin and Bacteria."],"pmcid":["PMC5539864"],"pubmed_authors":["Kilcoyne M","Joshi L","O'Riordan N","Hickey RM"],"additional_accession":[]},"is_claimable":false,"name":"Exploitation of SPR to Investigate the Importance of Glycan Chains in the Interaction between Lactoferrin and Bacteria.","description":"Bovine lactoferrin (LF) has been shown to prevent adhesion to and invasion of mammalian cell lines by pathogenic bacteria, with evidence for direct bacterial binding by the milk glycoprotein. However, the glycosylation pattern of LF changes over the lactation cycle. In this study, we aim to investigate the effect that this variation has on the milk glycoprotein's ability to interact with pathogens. Surface plasmon resonance technology was employed to compare the binding of LF from colostrum (early lactation) and mature milk (late lactation) to a panel of pathogenic bacteria (Staphylococcus aureus, Escherichia coli, Cronobacter sakazakii, Streptococcus pneumoniae, Pseudomonas aeruginosa, Listeria monocytogenes and Salmonella typhimurium). Novel interactions with LF were identified for C. sa","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jun","modification":"2025-04-04T10:03:57.208Z","creation":"2019-03-27T02:52:23Z"},"accession":"S-EPMC5539864","cross_references":{"pubmed":["28653977"],"doi":["10.3390/s17071515"]}}