{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Papaioannou D"],"funding":["European Hematology Association","NCI NIH HHS"],"pagination":["1391-1400"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5541873"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["102(8)"],"pubmed_abstract":["Long non-coding ribonucleic acids (RNAs) are a novel class of RNA molecules, which are increasingly recognized as important molecular players in solid and hematologic malignancies. Herein we investigated whether long non-coding RNA expression is associated with clinical and molecular features, as well as outcome of younger adults (aged <60 years) with <i>de novo</i> cytogenetically normal acute myeloid leukemia. Whole transcriptome profiling was performed in a training (n=263) and a validation set (n=114). Using the training set, we identified 24 long non-coding RNAs associated with event-free survival. Linear combination of the weighted expression values of these transcripts yielded a prognostic score. In the validation set, patients with high scores had shorter disease-free (<i>P</i><0.0"],"journal":["Haematologica"],"pubmed_title":["Prognostic and biologic significance of long non-coding RNA profiling in younger adults with cytogenetically normal acute myeloid leukemia."],"pmcid":["PMC5541873"],"funding_grant_id":["U10 CA077658","U10 CA180882","P30 CA016058","R50 CA211524","R35 CA197734","U10 CA180861","U10 CA180850","U24 CA196171","U10 CA180821","P50 CA140158","TRTH73"],"pubmed_authors":["Orwick SJ","Kolitz JE","Bundschuh R","Uy GL","Yan P","Papaioannou D","Wang ES","Stone RM","Volinia S","Mrozek K","Lucas DM","Garzon R","Nicolet D","Blum W","Bloomfield CD","Carroll AJ","Kohlschmidt J","Powell BL","Byrd JC","Eisfeld AK","Caligiuri MA"],"additional_accession":[]},"is_claimable":false,"name":"Prognostic and biologic significance of long non-coding RNA profiling in younger adults with cytogenetically normal acute myeloid leukemia.","description":"Long non-coding ribonucleic acids (RNAs) are a novel class of RNA molecules, which are increasingly recognized as important molecular players in solid and hematologic malignancies. Herein we investigated whether long non-coding RNA expression is associated with clinical and molecular features, as well as outcome of younger adults (aged <60 years) with <i>de novo</i> cytogenetically normal acute myeloid leukemia. Whole transcriptome profiling was performed in a training (n=263) and a validation set (n=114). Using the training set, we identified 24 long non-coding RNAs associated with event-free survival. Linear combination of the weighted expression values of these transcripts yielded a prognostic score. In the validation set, patients with high scores had shorter disease-free (<i>P</i><0.0","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Aug","modification":"2026-05-05T20:53:25.18Z","creation":"2026-04-07T21:58:37.777Z"},"accession":"S-EPMC5541873","cross_references":{"pubmed":["28473620"],"doi":["10.3324/haematol.2017.166215"]}}