biostudies-literaturePapaioannou DEuropean Hematology AssociationNCI NIH HHS1391-1400https://www.ebi.ac.uk/biostudies/studies/S-EPMC5541873biostudies-literatureUnknown102(8)Long non-coding ribonucleic acids (RNAs) are a novel class of RNA molecules, which are increasingly recognized as important molecular players in solid and hematologic malignancies. Herein we investigated whether long non-coding RNA expression is associated with clinical and molecular features, as well as outcome of younger adults (aged <60 years) with <i>de novo</i> cytogenetically normal acute myeloid leukemia. Whole transcriptome profiling was performed in a training (n=263) and a validation set (n=114). Using the training set, we identified 24 long non-coding RNAs associated with event-free survival. Linear combination of the weighted expression values of these transcripts yielded a prognostic score. In the validation set, patients with high scores had shorter disease-free (<i>P</i><0.0HaematologicaPrognostic and biologic significance of long non-coding RNA profiling in younger adults with cytogenetically normal acute myeloid leukemia.PMC5541873U10 CA077658U10 CA180882P30 CA016058R50 CA211524R35 CA197734U10 CA180861U10 CA180850U24 CA196171U10 CA180821P50 CA140158TRTH73Orwick SJKolitz JEBundschuh RUy GLYan PPapaioannou DWang ESStone RMVolinia SMrozek KLucas DMGarzon RNicolet DBlum WBloomfield CDCarroll AJKohlschmidt JPowell BLByrd JCEisfeld AKCaligiuri MAfalsePrognostic and biologic significance of long non-coding RNA profiling in younger adults with cytogenetically normal acute myeloid leukemia.Long non-coding ribonucleic acids (RNAs) are a novel class of RNA molecules, which are increasingly recognized as important molecular players in solid and hematologic malignancies. Herein we investigated whether long non-coding RNA expression is associated with clinical and molecular features, as well as outcome of younger adults (aged <60 years) with <i>de novo</i> cytogenetically normal acute myeloid leukemia. Whole transcriptome profiling was performed in a training (n=263) and a validation set (n=114). Using the training set, we identified 24 long non-coding RNAs associated with event-free survival. Linear combination of the weighted expression values of these transcripts yielded a prognostic score. In the validation set, patients with high scores had shorter disease-free (<i>P</i><0.02017-01-01T00:00:00Z2017 Aug2026-05-05T20:53:25.18Z2026-04-07T21:58:37.777ZS-EPMC55418732847362010.3324/haematol.2017.166215