biostudies-literatureLalitha CScience and Engineering Research Board346https://www.ebi.ac.uk/biostudies/studies/S-EPMC5543099biostudies-literatureUnknown7The emergence and spread of pathogens harboring extended spectrum beta-lactamase (ESBL) like carbapenem resistant Gram negative bacteria are the major emerging threat to public health. Of particular concern <i>Klebsiella pneumoniae</i> carbapenamase- producing strains have been recorded worldwide. Catheter associated urinary tract infections (CAUTI) caused by <i>K. pneumoniae</i> are significantly associated with morbidity and mortality. Hence the present work was aimed to develop a strategy for addressing these issues through an innovative approach of antibiofilm and immunomodulation. These two independent activities were analyzed in a <i>Streptomyces</i> derived ASK2 bioactive compound. While analysing the effect of sub-minimum inhibitory concentrations (sub-MICs), 0.5x of Minimum InhibiFrontiers in cellular and infection microbiologyASK2 Bioactive Compound Inhibits MDR <i>Klebsiella pneumoniae</i> by Antibiofilm Activity, Modulating Macrophage Cytokines and Opsonophagocytosis.PMC5543099EMR/20l5/000648EMR/2016/007613SR/SO/HS-0073/2012Rathore SSRamakrishnan JMunusamy ALalitha CRaman TRamar MfalseASK2 Bioactive Compound Inhibits MDR <i>Klebsiella pneumoniae</i> by Antibiofilm Activity, Modulating Macrophage Cytokines and Opsonophagocytosis.The emergence and spread of pathogens harboring extended spectrum beta-lactamase (ESBL) like carbapenem resistant Gram negative bacteria are the major emerging threat to public health. Of particular concern <i>Klebsiella pneumoniae</i> carbapenamase- producing strains have been recorded worldwide. Catheter associated urinary tract infections (CAUTI) caused by <i>K. pneumoniae</i> are significantly associated with morbidity and mortality. Hence the present work was aimed to develop a strategy for addressing these issues through an innovative approach of antibiofilm and immunomodulation. These two independent activities were analyzed in a <i>Streptomyces</i> derived ASK2 bioactive compound. While analysing the effect of sub-minimum inhibitory concentrations (sub-MICs), 0.5x of Minimum Inhibi2017-01-01T00:00:00Z20172025-06-01T01:33:40.103Z2025-06-01T01:33:40.103ZS-EPMC55430992882488110.3389/fcimb.2017.00346