{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Hamada Y"],"pubmed_abstract":["Following to the computational expectation, our previously reported intriguing 1,3-proton shift of 4,4,4-trifluorobut-2-yn-1-ols was successfully extended to the 4,4,4-trifluorobut-2-en-1-ol system under metal-free conditions to afford the corresponding saturated ketones in high to excellent chemical yields using such a convenient and easy-to-handle base as DBU at the toluene refluxing temperature, and utilization of the corresponding optically active substrates unambiguously demonstrated that this transformation proceeded in a highly stereoselective fashion."],"journal":["Beilstein journal of organic chemistry"],"pagination":["1507-1512"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5550803"],"repository":["biostudies-literature"],"pubmed_title":["Base-promoted isomerization of CF<sub>3</sub>-containing allylic alcohols to the corresponding saturated ketones under metal-free conditions."],"pmcid":["PMC5550803"],"pubmed_authors":["Hamada Y","Kawasaki-Takasuka T","Yamazaki T"],"additional_accession":[]},"is_claimable":false,"name":"Base-promoted isomerization of CF<sub>3</sub>-containing allylic alcohols to the corresponding saturated ketones under metal-free conditions.","description":"Following to the computational expectation, our previously reported intriguing 1,3-proton shift of 4,4,4-trifluorobut-2-yn-1-ols was successfully extended to the 4,4,4-trifluorobut-2-en-1-ol system under metal-free conditions to afford the corresponding saturated ketones in high to excellent chemical yields using such a convenient and easy-to-handle base as DBU at the toluene refluxing temperature, and utilization of the corresponding optically active substrates unambiguously demonstrated that this transformation proceeded in a highly stereoselective fashion.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2025-04-05T14:18:51.858Z","creation":"2019-03-27T02:53:08Z"},"accession":"S-EPMC5550803","cross_references":{"pubmed":["28845194"],"doi":["10.3762/bjoc.13.149"]}}