biostudies-literatureMiranti EHIntramural NIH HHSUniversiteit StellenboschNCI NIH HHSNational Cancer Institute, Department of Health and Human Services1120-1129https://www.ebi.ac.uk/biostudies/studies/S-EPMC5550828biostudies-literatureUnknown141(6)Previous studies have found associations between one-carbon metabolism nutrients and risk of several cancers, but little is known regarding upper gastrointestinal tract (UGI) cancer. We analyzed prediagnostic serum concentrations of several one-carbon metabolism nutrients (vitamin B12, folate, vitamin B6, riboflavin and homocysteine) in a nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study of male smokers, which was undertaken in Finland between 1985 and 1988. We conducted a nested case-control study including 127 noncardia gastric adenocarcinoma (NCGA), 41 esophagogastric junctional adenocarcinoma and 60 esophageal squamous cell carcinoma incident cases identified within ATBC. Controls were matched to cases on age, date of serum collection aInternational journal of cancerLow vitamin B₁₂ increases risk of gastric cancer: A prospective study of one-carbon metabolism nutrients and risk of upper gastrointestinal tract cancer.PMC5550828Z99 CA999999HHSN261201500005CAlbanes DSelhub JMannisto SFreedman NDMiranti EHMurphy GTaylor PRStolzenberg-Solomon RAbnet CCWeinstein SJfalseLow vitamin B₁₂ increases risk of gastric cancer: A prospective study of one-carbon metabolism nutrients and risk of upper gastrointestinal tract cancer.Previous studies have found associations between one-carbon metabolism nutrients and risk of several cancers, but little is known regarding upper gastrointestinal tract (UGI) cancer. We analyzed prediagnostic serum concentrations of several one-carbon metabolism nutrients (vitamin B12, folate, vitamin B6, riboflavin and homocysteine) in a nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study of male smokers, which was undertaken in Finland between 1985 and 1988. We conducted a nested case-control study including 127 noncardia gastric adenocarcinoma (NCGA), 41 esophagogastric junctional adenocarcinoma and 60 esophageal squamous cell carcinoma incident cases identified within ATBC. Controls were matched to cases on age, date of serum collection a2017-01-01T00:00:00Z2017 Sep2025-04-05T14:18:58.817Z2019-03-26T23:55:43ZS-EPMC55508282856805310.1002/ijc.30809