{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cullati SN"],"funding":["Dartmouth College","NCI NIH HHS","National Institutes of Health","NIGMS NIH HHS","NIH HHS"],"pagination":["2339-2354"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5551695"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["216(8)"],"pubmed_abstract":["In mitosis, cells undergo a precisely orchestrated series of spatiotemporal changes in cytoskeletal structure to divide their genetic material. These changes are coordinated by a sophisticated network of protein-protein interactions and posttranslational modifications. In this study, we report a bifurcation in a signaling cascade of the NIMA-related kinases (Neks) Nek6, Nek7, and Nek9 that is required for the localization and function of two kinesins essential for cytokinesis, Mklp2 and Kif14. We demonstrate that a Nek9, Nek6, and Mklp2 signaling module controls the timely localization and bundling activity of Mklp2 at the anaphase central spindle. We further show that a separate Nek9, Nek7, and Kif14 signaling module is required for the recruitment of the Rho-interacting kinase citron to "],"journal":["The Journal of cell biology"],"pubmed_title":["A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase."],"pmcid":["PMC5551695"],"funding_grant_id":["R01-CA155260","P20 GM103413","T32-GM008704","P20 GM113132","S10-OD016212","R35-GM119455","R35 GM119455","S10 OD016212","T32 GM008704","R01 CA155260","P20-GM103413"],"pubmed_authors":["Gerber SA","Kettenbach AN","Kabeche L","Cullati SN"],"additional_accession":[]},"is_claimable":false,"name":"A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase.","description":"In mitosis, cells undergo a precisely orchestrated series of spatiotemporal changes in cytoskeletal structure to divide their genetic material. These changes are coordinated by a sophisticated network of protein-protein interactions and posttranslational modifications. In this study, we report a bifurcation in a signaling cascade of the NIMA-related kinases (Neks) Nek6, Nek7, and Nek9 that is required for the localization and function of two kinesins essential for cytokinesis, Mklp2 and Kif14. We demonstrate that a Nek9, Nek6, and Mklp2 signaling module controls the timely localization and bundling activity of Mklp2 at the anaphase central spindle. We further show that a separate Nek9, Nek7, and Kif14 signaling module is required for the recruitment of the Rho-interacting kinase citron to ","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Aug","modification":"2025-04-04T22:50:20.925Z","creation":"2019-10-30T08:12:46Z"},"accession":"S-EPMC5551695","cross_references":{"pubmed":["28630147"],"doi":["10.1083/jcb.201512055"]}}