biostudies-literatureDrelich AJNIBIB NIH HHSNational Heart, Lung, and Blood InstituteNHLBI NIH HHSNational Institutes of HealthNational Institute of Biomedical Imaging and Bioengineering539-549https://www.ebi.ac.uk/biostudies/studies/S-EPMC5553077biostudies-literatureUnknown58Metallic zinc implanted into the abdominal aorta of rats out to 6months has been demonstrated to degrade while avoiding responses commonly associated with the restenosis of vascular implants. However, major questions remain regarding whether a zinc implant would ultimately passivate through the production of stable corrosion products or via a cell mediated fibrous encapsulation process that prevents the diffusion of critical reactants and products at the metal surface. Here, we have conducted clinically relevant long term in vivo studies in order to characterize late stage zinc implant biocorrosion behavior and products to address these critical questions. We found that zinc wires implanted in the murine artery exhibit steady corrosion without local toxicity for up to at least 20months posActa biomaterialiaLong-term surveillance of zinc implant in murine artery: Surprisingly steady biocorrosion rate.PMC5553077R15 HL1291991R15 HL129199-015R21EB 019118-02R21 EB019118Drelich AJZhao SGoldman JDrelich JWGuillory RJfalseLong-term surveillance of zinc implant in murine artery: Surprisingly steady biocorrosion rate.Metallic zinc implanted into the abdominal aorta of rats out to 6months has been demonstrated to degrade while avoiding responses commonly associated with the restenosis of vascular implants. However, major questions remain regarding whether a zinc implant would ultimately passivate through the production of stable corrosion products or via a cell mediated fibrous encapsulation process that prevents the diffusion of critical reactants and products at the metal surface. Here, we have conducted clinically relevant long term in vivo studies in order to characterize late stage zinc implant biocorrosion behavior and products to address these critical questions. We found that zinc wires implanted in the murine artery exhibit steady corrosion without local toxicity for up to at least 20months pos2017-01-01T00:00:00Z2017 Aug2025-04-05T11:13:03.608Z2019-03-26T23:48:40ZS-EPMC55530772853290110.1016/j.actbio.2017.05.045