biostudies-literatureHernandes MSNHLBI NIH HHS335-342https://www.ebi.ac.uk/biostudies/studies/S-EPMC5556945biostudies-literatureUnknown69(6)Polymerase ?-interacting protein 2 (Poldip2) is a multifunctional protein originally described as a binding partner of the p50 subunit of DNA polymerase ? and proliferating cell nuclear antigen. In addition to its role in DNA replication and damage repair, Poldip2 has been implicated in mitochondrial function, extracellular matrix regulation, cell cycle progression, focal adhesion turnover, and cell migration. However, Poldip2 functions are incompletely understood. In this review, we discuss recent literature on Poldip2 tissue distribution, subcellular localization, and function. We also address the putative function of Poldip2 in cardiovascular disease, neurodegenerative conditions and in renal pathophysiology.Journal of cardiovascular pharmacologyPolymerase ?-interacting Protein 2: A Multifunctional Protein.PMC5556945R01 HL038206P01 HL095070R37 HL038206Lassegue BGriendling KKHernandes MSfalsePolymerase ?-interacting Protein 2: A Multifunctional Protein.Polymerase ?-interacting protein 2 (Poldip2) is a multifunctional protein originally described as a binding partner of the p50 subunit of DNA polymerase ? and proliferating cell nuclear antigen. In addition to its role in DNA replication and damage repair, Poldip2 has been implicated in mitochondrial function, extracellular matrix regulation, cell cycle progression, focal adhesion turnover, and cell migration. However, Poldip2 functions are incompletely understood. In this review, we discuss recent literature on Poldip2 tissue distribution, subcellular localization, and function. We also address the putative function of Poldip2 in cardiovascular disease, neurodegenerative conditions and in renal pathophysiology.2017-01-01T00:00:00Z2017 Jun2020-11-19T16:46:19Z2019-06-06T17:56:26ZS-EPMC55569452857495310.1097/fjc.000000000000046510.1097/FJC.0000000000000465