{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Boyce MW"],"funding":["National Institute of General Medical Sciences","Eli Lilly and Company","NIGMS NIH HHS","National Science Foundation"],"pagination":["2819-2827"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5557652"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["142(15)"],"pubmed_abstract":["In vitro models for screening new cancer chemotherapeutics often rely on two-dimensional cultures to predict therapeutic potential. Unfortunately, the predictive power of these models is limited, as they fail to recapitulate the complex three-dimensional environments in tumors that promote a chemoresistant phenotype. In this study, we describe the preparation and characterization of paper-based cultures (PBCs) engineered to assess chemotherapeutic effectiveness in three dimensional, diffusion-limited environments. Similar environments are found in poorly vascularized tumors. Monotonic gradients develop across these cultures, which are assembled by stacking cell-laden paper scaffolds to yield thick tissue-like structures, and provide distinct chemical environments for each scaffold. After p"],"journal":["The Analyst"],"pubmed_title":["Assessing chemotherapeutic effectiveness using a paper-based tumor model."],"pmcid":["PMC5557652"],"funding_grant_id":["R01 GM110406","CHE-1351595","R01GM110406","Lilly Young Investigator Award in Analytical Chemistry"],"pubmed_authors":["Boyce MW","Lockett MR","LaBonia GJ","Hummon AB"],"additional_accession":[]},"is_claimable":false,"name":"Assessing chemotherapeutic effectiveness using a paper-based tumor model.","description":"In vitro models for screening new cancer chemotherapeutics often rely on two-dimensional cultures to predict therapeutic potential. Unfortunately, the predictive power of these models is limited, as they fail to recapitulate the complex three-dimensional environments in tumors that promote a chemoresistant phenotype. In this study, we describe the preparation and characterization of paper-based cultures (PBCs) engineered to assess chemotherapeutic effectiveness in three dimensional, diffusion-limited environments. Similar environments are found in poorly vascularized tumors. Monotonic gradients develop across these cultures, which are assembled by stacking cell-laden paper scaffolds to yield thick tissue-like structures, and provide distinct chemical environments for each scaffold. After p","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jul","modification":"2025-04-19T08:43:30.697Z","creation":"2019-03-26T23:47:20Z"},"accession":"S-EPMC5557652","cross_references":{"pubmed":["28702529"],"doi":["10.1039/c7an00806f"]}}