{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Geiger H"],"funding":["NIA NIH HHS"],"pagination":["5102-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC555968"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["102(14)"],"pubmed_abstract":["Until recently, stem cells were thought to be endowed with unlimited self-renewal capacity and, thus, assumed exempt from aging. But accumulating evidence over the past decade compellingly argues that a measurable and progressive replicative impairment in the hematopoietic, intestinal, and muscle stem cell activity exists from adulthood to old age, resulting in a decline in stem cell function and rendering stem cell aging as the possible link between cellular aging and organismal aging. By using a previously uncharacterized congenic animal model to study genetic regulation of hematopoietic stem cell aging, we have demonstrated definitively that a locus on murine chromosome 2 regulates hematopoietic stem cell aging. In addition to demonstrating that hematopoietic stem cell aging is regulate"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Regulation of hematopoietic stem cell aging in vivo by a distinct genetic element."],"pmcid":["PMC555968"],"funding_grant_id":["AG16653","R01 AG020917","AG20917"],"pubmed_authors":["Van Zant G","Geiger H","Rennebeck G"],"additional_accession":[]},"is_claimable":false,"name":"Regulation of hematopoietic stem cell aging in vivo by a distinct genetic element.","description":"Until recently, stem cells were thought to be endowed with unlimited self-renewal capacity and, thus, assumed exempt from aging. But accumulating evidence over the past decade compellingly argues that a measurable and progressive replicative impairment in the hematopoietic, intestinal, and muscle stem cell activity exists from adulthood to old age, resulting in a decline in stem cell function and rendering stem cell aging as the possible link between cellular aging and organismal aging. By using a previously uncharacterized congenic animal model to study genetic regulation of hematopoietic stem cell aging, we have demonstrated definitively that a locus on murine chromosome 2 regulates hematopoietic stem cell aging. In addition to demonstrating that hematopoietic stem cell aging is regulate","dates":{"release":"2005-01-01T00:00:00Z","publication":"2005 Apr","modification":"2025-06-01T00:32:18.344Z","creation":"2025-06-01T00:32:18.344Z"},"accession":"S-EPMC555968","cross_references":{"pubmed":["15788535"],"doi":["10.1073/pnas.0408654102"]}}