biostudies-literatureGeiger HNIA NIH HHS5102-7https://www.ebi.ac.uk/biostudies/studies/S-EPMC555968biostudies-literatureUnknown102(14)Until recently, stem cells were thought to be endowed with unlimited self-renewal capacity and, thus, assumed exempt from aging. But accumulating evidence over the past decade compellingly argues that a measurable and progressive replicative impairment in the hematopoietic, intestinal, and muscle stem cell activity exists from adulthood to old age, resulting in a decline in stem cell function and rendering stem cell aging as the possible link between cellular aging and organismal aging. By using a previously uncharacterized congenic animal model to study genetic regulation of hematopoietic stem cell aging, we have demonstrated definitively that a locus on murine chromosome 2 regulates hematopoietic stem cell aging. In addition to demonstrating that hematopoietic stem cell aging is regulateProceedings of the National Academy of Sciences of the United States of AmericaRegulation of hematopoietic stem cell aging in vivo by a distinct genetic element.PMC555968AG16653R01 AG020917AG20917Van Zant GGeiger HRennebeck GfalseRegulation of hematopoietic stem cell aging in vivo by a distinct genetic element.Until recently, stem cells were thought to be endowed with unlimited self-renewal capacity and, thus, assumed exempt from aging. But accumulating evidence over the past decade compellingly argues that a measurable and progressive replicative impairment in the hematopoietic, intestinal, and muscle stem cell activity exists from adulthood to old age, resulting in a decline in stem cell function and rendering stem cell aging as the possible link between cellular aging and organismal aging. By using a previously uncharacterized congenic animal model to study genetic regulation of hematopoietic stem cell aging, we have demonstrated definitively that a locus on murine chromosome 2 regulates hematopoietic stem cell aging. In addition to demonstrating that hematopoietic stem cell aging is regulate2005-01-01T00:00:00Z2005 Apr2025-06-01T00:32:18.344Z2025-06-01T00:32:18.344ZS-EPMC5559681578853510.1073/pnas.0408654102