{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Avegno EM"],"funding":["National Institute on Alcohol Abuse and Alcoholism","NIDA NIH HHS","UCSF","NIAAA NIH HHS","National Institute on Drug Abuse"],"pagination":["386-395"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5563459"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["110(Pt A)"],"pubmed_abstract":["Enhanced dopamine (DA) neurotransmission from the ventral tegmental area (VTA) to the ventral striatum is thought to drive drug self-administration and mediate positive reinforcement. We examined neuronal firing rates in slices of mouse midbrain following adolescent binge-like alcohol drinking and find that prior alcohol experience greatly enhanced the sensitivity to excitation by ethanol itself (10-50 mM) in a subset of ventral midbrain DA neurons located in the medial VTA. This enhanced response after drinking was not associated with alterations of firing rate or other measures of intrinsic excitability. In addition, the phenomenon appears to be specific to adolescent drinking, as mice that established a drinking preference only after the onset of adulthood showed no change in alcohol sensitivity. Here we demonstrate not only that drinking during adolescence induces enhanced alcohol sensitivity, but also that this DA neuronal response occurs over a range of alcohol concentrations associated with social drinking in humans."],"journal":["Neuropharmacology"],"pubmed_title":["Voluntary adolescent drinking enhances excitation by low levels of alcohol in a subset of dopaminergic neurons in the ventral tegmental area."],"pmcid":["PMC5563459"],"funding_grant_id":["R01 AA019801","AA022028","P01 DA010154","F31 AA023714","DA07418","R01 AA023531","AA23531","F32 AA022028","AA023714","AA19801","R01 DA007418","DA10154"],"pubmed_authors":["Harrison NL","Avegno EM","Salling MC","Margolis EB","Mrejeru A","Whitebirch AC","Borgkvist A","Sulzer D"],"additional_accession":[]},"is_claimable":false,"name":"Voluntary adolescent drinking enhances excitation by low levels of alcohol in a subset of dopaminergic neurons in the ventral tegmental area.","description":"Enhanced dopamine (DA) neurotransmission from the ventral tegmental area (VTA) to the ventral striatum is thought to drive drug self-administration and mediate positive reinforcement. We examined neuronal firing rates in slices of mouse midbrain following adolescent binge-like alcohol drinking and find that prior alcohol experience greatly enhanced the sensitivity to excitation by ethanol itself (10-50 mM) in a subset of ventral midbrain DA neurons located in the medial VTA. This enhanced response after drinking was not associated with alterations of firing rate or other measures of intrinsic excitability. In addition, the phenomenon appears to be specific to adolescent drinking, as mice that established a drinking preference only after the onset of adulthood showed no change in alcohol sensitivity. Here we demonstrate not only that drinking during adolescence induces enhanced alcohol sensitivity, but also that this DA neuronal response occurs over a range of alcohol concentrations associated with social drinking in humans.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Nov","modification":"2024-12-04T11:09:40.604Z","creation":"2019-03-27T02:53:59Z"},"accession":"S-EPMC5563459","cross_references":{"pubmed":["27475082"],"doi":["10.1016/j.neuropharm.2016.07.031"]}}