{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Krischer JP"],"funding":["National Center for Advancing Translational Sciences","NCATS NIH HHS","NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","National Institutes of Health"],"pagination":["1194-1202"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5566280"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["40(9)"],"pubmed_abstract":["<h4>Objective</h4>We tested the associations between genetic background and selected environmental exposures with respect to islet autoantibodies and type 1 diabetes.<h4>Research design and methods</h4>Infants with HLA-DR high-risk genotypes were prospectively followed for diabetes-related autoantibodies. Single nucleotide polymorphisms (SNPs) came from the Illumina ImmunoChip and environmental exposure data were by parental report. Children were followed to age 6 years.<h4>Results</h4>Insulin autoantibodies occurred earlier than GAD antibody (GADA) and then declined, while GADA incidence rose and remained constant (significant in HLA-DR4 but not in the DR3/3 children). The presence of SNPs rs2476601 (<i>PTPN22</i>) and rs2292239 (<i>ERBB3</i>) demonstrated increased risk of both autoantib"],"journal":["Diabetes care"],"pubmed_title":["Genetic and Environmental Interactions Modify the Risk of Diabetes-Related Autoimmunity by 6 Years of Age: The TEDDY Study."],"pmcid":["PMC5566280"],"funding_grant_id":["U01 DK063861","UC4 DK063836","UC4-DK-63829","UC4 DK117483","UC4-DK-95300","U01 DK063821","U01 DK063865","UL1 TR001427","U01 DK063863","U01-DK-63790","UC4-DK-63836","UC4 DK112243","U01-DK-63836","UC4 DK095300","UL1 TR000064","U01-DK-63829","U01 DK063790","UC4 DK063863","UC4 DK063865","UC4 DK063821","U01 DK063836","UC4 DK063861","UC4 DK100238","UC4 DK106955","UC4-DK-63861","U01 DK063829","U01-DK-63861","HHSN267200700014C","U01-DK-63863","U01-DK-63865","U01-DK-63821","UC4-DK-63865","UC4-DK-63821","UL1 TR001082","UC4-DK-63863","UC4 DK063829"],"pubmed_authors":["Krischer JP","Hagopian WA","She JX","Ziegler AG","TEDDY Study Group","Lynch KF","Rewers MJ","Akolkar B","Toppari J","Lernmark A"],"additional_accession":[]},"is_claimable":false,"name":"Genetic and Environmental Interactions Modify the Risk of Diabetes-Related Autoimmunity by 6 Years of Age: The TEDDY Study.","description":"<h4>Objective</h4>We tested the associations between genetic background and selected environmental exposures with respect to islet autoantibodies and type 1 diabetes.<h4>Research design and methods</h4>Infants with HLA-DR high-risk genotypes were prospectively followed for diabetes-related autoantibodies. Single nucleotide polymorphisms (SNPs) came from the Illumina ImmunoChip and environmental exposure data were by parental report. Children were followed to age 6 years.<h4>Results</h4>Insulin autoantibodies occurred earlier than GAD antibody (GADA) and then declined, while GADA incidence rose and remained constant (significant in HLA-DR4 but not in the DR3/3 children). The presence of SNPs rs2476601 (<i>PTPN22</i>) and rs2292239 (<i>ERBB3</i>) demonstrated increased risk of both autoantib","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Sep","modification":"2026-05-04T16:15:26.391Z","creation":"2019-03-26T23:53:49Z"},"accession":"S-EPMC5566280","cross_references":{"pubmed":["28646072"],"doi":["10.2337/dc17-0238"]}}