biostudies-literatureKrischer JPNational Center for Advancing Translational SciencesNCATS NIH HHSNIDDK NIH HHSNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of Health1194-1202https://www.ebi.ac.uk/biostudies/studies/S-EPMC5566280biostudies-literatureUnknown40(9)<h4>Objective</h4>We tested the associations between genetic background and selected environmental exposures with respect to islet autoantibodies and type 1 diabetes.<h4>Research design and methods</h4>Infants with HLA-DR high-risk genotypes were prospectively followed for diabetes-related autoantibodies. Single nucleotide polymorphisms (SNPs) came from the Illumina ImmunoChip and environmental exposure data were by parental report. Children were followed to age 6 years.<h4>Results</h4>Insulin autoantibodies occurred earlier than GAD antibody (GADA) and then declined, while GADA incidence rose and remained constant (significant in HLA-DR4 but not in the DR3/3 children). The presence of SNPs rs2476601 (<i>PTPN22</i>) and rs2292239 (<i>ERBB3</i>) demonstrated increased risk of both autoantibDiabetes careGenetic and Environmental Interactions Modify the Risk of Diabetes-Related Autoimmunity by 6 Years of Age: The TEDDY Study.PMC5566280U01 DK063861UC4 DK063836UC4-DK-63829UC4 DK117483UC4-DK-95300U01 DK063821U01 DK063865UL1 TR001427U01 DK063863U01-DK-63790UC4-DK-63836UC4 DK112243U01-DK-63836UC4 DK095300UL1 TR000064U01-DK-63829U01 DK063790UC4 DK063863UC4 DK063865UC4 DK063821U01 DK063836UC4 DK063861UC4 DK100238UC4 DK106955UC4-DK-63861U01 DK063829U01-DK-63861HHSN267200700014CU01-DK-63863U01-DK-63865U01-DK-63821UC4-DK-63865UC4-DK-63821UL1 TR001082UC4-DK-63863UC4 DK063829Krischer JPHagopian WAShe JXZiegler AGTEDDY Study GroupLynch KFRewers MJAkolkar BToppari JLernmark AfalseGenetic and Environmental Interactions Modify the Risk of Diabetes-Related Autoimmunity by 6 Years of Age: The TEDDY Study.<h4>Objective</h4>We tested the associations between genetic background and selected environmental exposures with respect to islet autoantibodies and type 1 diabetes.<h4>Research design and methods</h4>Infants with HLA-DR high-risk genotypes were prospectively followed for diabetes-related autoantibodies. Single nucleotide polymorphisms (SNPs) came from the Illumina ImmunoChip and environmental exposure data were by parental report. Children were followed to age 6 years.<h4>Results</h4>Insulin autoantibodies occurred earlier than GAD antibody (GADA) and then declined, while GADA incidence rose and remained constant (significant in HLA-DR4 but not in the DR3/3 children). The presence of SNPs rs2476601 (<i>PTPN22</i>) and rs2292239 (<i>ERBB3</i>) demonstrated increased risk of both autoantib2017-01-01T00:00:00Z2017 Sep2026-05-04T16:15:26.391Z2019-03-26T23:53:49ZS-EPMC55662802864607210.2337/dc17-0238