biostudies-literatureKritchevsky SBNICHD NIH HHSNIA NIH HHSNCRR NIH HHS1199-1205https://www.ebi.ac.uk/biostudies/studies/S-EPMC5567861biostudies-literatureUnknown25(7)<h4>Objective</h4>Some data suggest that obesity blunts the benefits of exercise on mobility in older adults. This study tested the homogeneity of the effect of a physical activity intervention on major mobility disability (MMD) across baseline obesity classifications in the Lifestyle Interventions and Independence for Elders (LIFE) Study. LIFE randomized 1,635 sedentary men and women aged 70 to 89 years to a moderate-intensity physical activity (PA) or health education program.<h4>Methods</h4>MMD, defined as the inability to walk 400 m, was determined over an average follow-up of 2.6 years. Participants were divided into four subgroups: (1) nonobese (BMI?<?30 kg/m² ; n?=?437); (2) nonobese with high waist circumference (WC?>?102 cm [men],?>?88?cm [women]; n?=?434); (3) class 1 obesity (30 kg/m² ???BMI?<?35?kg/m² ; n?=?430); and (4) class 2?+?obesity (BMI???35 kg/m² ; n?=?312). Cox proportional hazard modeling was used to test an obesity by intervention interaction.<h4>Results</h4>The PA intervention had the largest benefit in participants with class 2?+?obesity (hazard ratio 0.69, 95% confidence interval 0.48, 0.98). However, there was no statistically significant difference in benefit across obesity categories.<h4>Conclusions</h4>A structured PA program reduced the risk of MMD even in older adults with extreme obesity.Obesity (Silver Spring, Md.)Exercise's effect on mobility disability in older adults with and without obesity: The LIFE study randomized clinical trial.PMC5567861P30 AG021332U01 AG022376UL1 RR025744P30 AG021342P30 AG028740P30 AG031679P30 AG024827R24 HD065688K07 AG043587Pahor MLovato LKritchevsky SBHanding EPKing ASpring BBotoseneanu ARejeski WJManini TGuralnik JMLiu CBlair SMarsh APfalseExercise's effect on mobility disability in older adults with and without obesity: The LIFE study randomized clinical trial.<h4>Objective</h4>Some data suggest that obesity blunts the benefits of exercise on mobility in older adults. This study tested the homogeneity of the effect of a physical activity intervention on major mobility disability (MMD) across baseline obesity classifications in the Lifestyle Interventions and Independence for Elders (LIFE) Study. LIFE randomized 1,635 sedentary men and women aged 70 to 89 years to a moderate-intensity physical activity (PA) or health education program.<h4>Methods</h4>MMD, defined as the inability to walk 400 m, was determined over an average follow-up of 2.6 years. Participants were divided into four subgroups: (1) nonobese (BMI?<?30 kg/m² ; n?=?437); (2) nonobese with high waist circumference (WC?>?102 cm [men],?>?88?cm [women]; n?=?434); (3) class 1 obesity (30 kg/m² ???BMI?<?35?kg/m² ; n?=?430); and (4) class 2?+?obesity (BMI???35 kg/m² ; n?=?312). Cox proportional hazard modeling was used to test an obesity by intervention interaction.<h4>Results</h4>The PA intervention had the largest benefit in participants with class 2?+?obesity (hazard ratio 0.69, 95% confidence interval 0.48, 0.98). However, there was no statistically significant difference in benefit across obesity categories.<h4>Conclusions</h4>A structured PA program reduced the risk of MMD even in older adults with extreme obesity.2017-01-01T00:00:00Z2017 Jul2021-02-20T23:22:37Z2019-03-26T23:44:06ZS-EPMC55678612865349910.1002/oby.21860