biostudies-literatureChristophersen IENCATS NIH HHSNIDDK NIH HHSNHLBI NIH HHSe001667https://www.ebi.ac.uk/biostudies/studies/S-EPMC5567993biostudies-literatureUnknown10(4)<h4>Background</h4>The P wave on an ECG is a measure of atrial electric function, and its characteristics may serve as predictors for atrial arrhythmias. Increased mean P-wave duration and P-wave terminal force traditionally have been used as markers for left atrial enlargement, and both have been associated with increased risk of atrial fibrillation. Here, we explore the genetic basis of P-wave morphology through meta-analysis of genome-wide association study results for P-wave duration and P-wave terminal force from 12 cohort studies.<h4>Methods and results</h4>We included 44 456 individuals, of which 6778 (16%) were of African ancestry. Genotyping, imputation, and genome-wide association study were performed at each study site. Summary-level results were meta-analyzed centrally using inCirculation. Cardiovascular geneticsFifteen Genetic Loci Associated With the Electrocardiographic P Wave.PMC5567993K23 HL114724UL1 TR000124UL1 TR001881K24 HL105780R01 HL120393R01 HL116747R01 HL090620R01 HL092577R01 HL111314U01 HL120393P30 DK063491R01 HL105756R01 HL128914U01 HL130114Peters APsaty BMRotter JISoliman EZSinner MFChung MKWhitsel EAAvery CLBuzkova PVan Wagoner DRUitterlinden AMeitinger TAlonso AStricker BHFelix SBKors JAEllinor PTLimacher MCWilhelmsen KCLi YMuller CMuller-Nurasyid MMagnani JWSchnabel RBKrijthe BPDorr MChristophersen IEWaldenberger MWeng LCNiemeijer MNKerr KFSotoodehnia Nvan Duijn CIsaacs AHofman ALubitz SASmith JDBenjamin EJYin XReiner APDuan QTinker LFVolker UHeckbert SRBis JCArking DEZhang ZMKaab STeumer ABarnard JPetersmann ANorth KEfalseFifteen Genetic Loci Associated With the Electrocardiographic P Wave.<h4>Background</h4>The P wave on an ECG is a measure of atrial electric function, and its characteristics may serve as predictors for atrial arrhythmias. Increased mean P-wave duration and P-wave terminal force traditionally have been used as markers for left atrial enlargement, and both have been associated with increased risk of atrial fibrillation. Here, we explore the genetic basis of P-wave morphology through meta-analysis of genome-wide association study results for P-wave duration and P-wave terminal force from 12 cohort studies.<h4>Methods and results</h4>We included 44 456 individuals, of which 6778 (16%) were of African ancestry. Genotyping, imputation, and genome-wide association study were performed at each study site. Summary-level results were meta-analyzed centrally using in2017-01-01T00:00:00Z2017 Aug2026-05-03T21:06:10.231Z2019-03-26T23:48:43ZS-EPMC55679932879411210.1161/CIRCGENETICS.116.00166710.1161/circgenetics.116.001667