{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Curtit E"],"funding":["INCa"],"pagination":["98"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5568360"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["<h4>Background</h4>Genome-wide association studies (GWAS) have to date identified 94 genetic variants (single nucleotide polymorphisms (SNPs)) associated with risk of developing breast cancer. A score based on the combined effect of the 94 risk alleles can be calculated to measure the global risk of breast cancer. We aimed to test the hypothesis that the 94-SNP-based risk score is associated with clinico-pathological characteristics, breast cancer subtypes and outcomes in early breast cancer.<h4>Methods</h4>A 94-SNP risk score was calculated in 8703 patients in the PHARE and SIGNAL prospective case cohorts. This score is the total number of inherited risk alleles based on 94 selected SNPs. Clinical data and outcomes were prospectively registered. Genotyping was obtained from a GWAS.<h4>Res"],"journal":["Breast cancer research : BCR"],"pubmed_title":["Assessment of the prognostic role of a 94-single nucleotide polymorphisms risk score in early breast cancer in the SIGNAL/PHARE prospective cohort: no correlation with clinico-pathological characteristics and outcomes."],"pmcid":["PMC5568360"],"funding_grant_id":["PHARE-Signal translational project"],"pubmed_authors":["Soulie P","Rios M","Pauporte I","Pivot X","Levy C","Thomas G","Cojocarasu O","Boland A","Tarpin C","Cox DG","Trillet-Lenoir V","Faure-Mercier C","Ferrero JM","Bacq D","Tennevet I","Sahbatou M","Besse C","Meunier J","Curtit E","Mathieu MC","Bonnefoi H","Delecroix V","Blanche H","Jacquin JP","Assouline D","Kerbrat P","Deleuze JF","Paget-Bailly S","Lavau-Denes S","Fumoleau P","Bourgeois H","Romieu G","Darut-Jouve A","Pierga JY","Bachelot T","Jouannaud C","Petit T","Henriques J"],"additional_accession":[]},"is_claimable":false,"name":"Assessment of the prognostic role of a 94-single nucleotide polymorphisms risk score in early breast cancer in the SIGNAL/PHARE prospective cohort: no correlation with clinico-pathological characteristics and outcomes.","description":"<h4>Background</h4>Genome-wide association studies (GWAS) have to date identified 94 genetic variants (single nucleotide polymorphisms (SNPs)) associated with risk of developing breast cancer. A score based on the combined effect of the 94 risk alleles can be calculated to measure the global risk of breast cancer. We aimed to test the hypothesis that the 94-SNP-based risk score is associated with clinico-pathological characteristics, breast cancer subtypes and outcomes in early breast cancer.<h4>Methods</h4>A 94-SNP risk score was calculated in 8703 patients in the PHARE and SIGNAL prospective case cohorts. This score is the total number of inherited risk alleles based on 94 selected SNPs. Clinical data and outcomes were prospectively registered. Genotyping was obtained from a GWAS.<h4>Res","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Aug","modification":"2026-05-03T21:08:06.127Z","creation":"2019-03-27T02:54:18Z"},"accession":"S-EPMC5568360","cross_references":{"pubmed":["28830573"],"doi":["10.1186/s13058-017-0888-4"]}}