{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["48(4)"],"submitter":["Wu T"],"pubmed_abstract":["Liver injury has a critical effect on the severity and outcome of sepsis. The impact of stored red blood cells (RBCs) on the pathogenesis of sepsis-associated hepatic injury is not well understood. Therefore, to investigate the effects of stored-RBC transfusion on sepsis-induced liver damage as well as the associated mechanism, we constructed a sepsis mouse model enabling noninvasive imaging of bacterial infection caused by Pseudomonas aeruginosa, a common gram-negative respiratory pathogen. We showed that transfusions with stored RBCs enhanced sepsis-induced liver injury in vivo, and liver injury exacerbated the severity of sepsis and decreased survival in P aeruginosa-infected mice. Stored-RBC transfusions enhanced the production of proinflammatory cytokines such as tumor necrosis factor"],"journal":["Shock (Augusta, Ga.)"],"pagination":["459-466"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5571877"],"repository":["biostudies-literature"],"pubmed_title":["Noninvasive Imaging of Stored Red Blood Cell-Transfusion Aggravating Sepsis-Induced Liver Injury Associated with Increased Activation of M1-Polarized Kupffer Cells."],"pmcid":["PMC5571877"],"pubmed_authors":["Wu CY","An J","Fu QX","Wang XH","Wang L","Zhang YL","Zhou QQ","Wang HF","Wu T","Wang Y","Qian L","Zhan LS","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"Noninvasive Imaging of Stored Red Blood Cell-Transfusion Aggravating Sepsis-Induced Liver Injury Associated with Increased Activation of M1-Polarized Kupffer Cells.","description":"Liver injury has a critical effect on the severity and outcome of sepsis. The impact of stored red blood cells (RBCs) on the pathogenesis of sepsis-associated hepatic injury is not well understood. Therefore, to investigate the effects of stored-RBC transfusion on sepsis-induced liver damage as well as the associated mechanism, we constructed a sepsis mouse model enabling noninvasive imaging of bacterial infection caused by Pseudomonas aeruginosa, a common gram-negative respiratory pathogen. We showed that transfusions with stored RBCs enhanced sepsis-induced liver injury in vivo, and liver injury exacerbated the severity of sepsis and decreased survival in P aeruginosa-infected mice. Stored-RBC transfusions enhanced the production of proinflammatory cytokines such as tumor necrosis factor","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Oct","modification":"2025-04-05T10:47:24.772Z","creation":"2019-03-27T02:54:33Z"},"accession":"S-EPMC5571877","cross_references":{"pubmed":["28333715"],"doi":["10.1097/SHK.0000000000000867"]}}