{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Steinhoff MC"],"funding":["Centers for Disease Control and Prevention","NIAID NIH HHS","Bill and Melinda Gates Foundation"],"pagination":["981-989"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5573632"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(9)"],"pubmed_abstract":["Background
Influenza immunisation during pregnancy is recommended but not widely implemented in some low-income regions. We assessed the safety and efficacy in mothers and infants of year-round maternal influenza immunisation in Nepal, where influenza viruses circulate throughout the year.Methods
In this phase 4, randomised, placebo-controlled trial, we enrolled two consecutive sequential annual cohorts of pregnant women from the Sarlahi district in southern Nepal. We randomised mothers 1:1 to receive seasonally recommended trivalent inactivated influenza vaccine or saline placebo in blocks of eight, stratified by gestational age at enrolment (17-25 weeks vs 26-34 weeks). Women were eligible if they were married, 15-40 years of age, 17-34 weeks' gestation at enrolment, and "],"journal":["The Lancet. Infectious diseases"],"pubmed_title":["Year-round influenza immunisation during pregnancy in Nepal: a phase 4, randomised, placebo-controlled trial."],"pmcid":["PMC5573632"],"funding_grant_id":["L30 AI107833","50274","K23 AI103105"],"pubmed_authors":["Steinhoff MC","Chu HY","Reedy AM","Kuypers J","Tielsch JM","Shrestha L","Englund JA","Katz J","Khatry SK","Kozuki N","Stewart L","Mullany LC","LeClerq SC","McNeal M"],"additional_accession":[]},"is_claimable":false,"name":"Year-round influenza immunisation during pregnancy in Nepal: a phase 4, randomised, placebo-controlled trial.","description":"Background
Influenza immunisation during pregnancy is recommended but not widely implemented in some low-income regions. We assessed the safety and efficacy in mothers and infants of year-round maternal influenza immunisation in Nepal, where influenza viruses circulate throughout the year.Methods
In this phase 4, randomised, placebo-controlled trial, we enrolled two consecutive sequential annual cohorts of pregnant women from the Sarlahi district in southern Nepal. We randomised mothers 1:1 to receive seasonally recommended trivalent inactivated influenza vaccine or saline placebo in blocks of eight, stratified by gestational age at enrolment (17-25 weeks vs 26-34 weeks). Women were eligible if they were married, 15-40 years of age, 17-34 weeks' gestation at enrolment, and ","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Sep","modification":"2026-05-04T15:16:46.389Z","creation":"2019-03-26T23:53:49Z"},"accession":"S-EPMC5573632","cross_references":{"pubmed":["28522338"],"doi":["10.1016/S1473-3099(17)30252-9","10.1016/s1473-3099(17)30252-9"]}}