{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(1)"],"submitter":["Shimamura M"],"pubmed_abstract":["Some synthetic and bacterial glycolipids presented by CD1d specifically activate invariant NKT (iNKT) cells bearing an invariant Vα14-Jα18 (mouse) or Vα24-Jα18 (human) TCR. The antigenic glycolipids identified to date consist of two hydrophobic chains and an α-glycoside in which the 2'-OH group is in the cis orientation toward the anomeric group, namely, either an α-galactoside or an α-glucoside. Several microbial α-mannosyl glycolipids, in which the 2'-OH group is in the trans orientation, were herein examined to establish whether they have potential to activate iNKT cells. We found that α-mannnosyl1-3 (6'-O-acyl α-mannosyl)-1-1 monoacylglycerol and cholesteryl 6'-O-acyl α-mannoside, found in Saccharopolyspora and Candida albicans, respectively, induced the activation of iNKT cells, depen"],"journal":["Scientific reports"],"pagination":["9703"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5574887"],"repository":["biostudies-literature"],"pubmed_title":["Activation of invariant natural killer T cells stimulated with microbial α-mannosyl glycolipids."],"pmcid":["PMC5574887"],"pubmed_authors":["van den Elzen P","Illarionov P","Yamamura M","Kitano N","Andrew P","Yesilkaya H","Shimamura M","Nabeshima T"],"additional_accession":[]},"is_claimable":false,"name":"Activation of invariant natural killer T cells stimulated with microbial α-mannosyl glycolipids.","description":"Some synthetic and bacterial glycolipids presented by CD1d specifically activate invariant NKT (iNKT) cells bearing an invariant Vα14-Jα18 (mouse) or Vα24-Jα18 (human) TCR. The antigenic glycolipids identified to date consist of two hydrophobic chains and an α-glycoside in which the 2'-OH group is in the cis orientation toward the anomeric group, namely, either an α-galactoside or an α-glucoside. Several microbial α-mannosyl glycolipids, in which the 2'-OH group is in the trans orientation, were herein examined to establish whether they have potential to activate iNKT cells. We found that α-mannnosyl1-3 (6'-O-acyl α-mannosyl)-1-1 monoacylglycerol and cholesteryl 6'-O-acyl α-mannoside, found in Saccharopolyspora and Candida albicans, respectively, induced the activation of iNKT cells, depen","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Aug","modification":"2025-04-19T03:30:40.233Z","creation":"2019-03-27T02:54:45Z"},"accession":"S-EPMC5574887","cross_references":{"pubmed":["28852174"],"doi":["10.1038/s41598-017-10309-x"]}}